Modulation of ultraviolet light-induced epidermal damage

Beneficial effects of tocopherol

Edmond F Ritter, Mac Axelrod, Kyung Won Minn, Edward Eades, Adam M. Rudner, Donald Serafin, Bruce Klitzman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Oxygen free radicals have been shown to result from and mediate deleterious effects of ultraviolet radiation on the skin. The purpose of this study was to determine if topical DL-α-tocopherol (vitamin E) could reduce ultravitier-induced damage to the epidermis. Twenty mice were treated with either ethanol or a 1:1 mixture of tocopherol and ethanol. Treatments consisted of once-daily 0.1-ml topical applications for 1 week, followed by irradiation with 0.30 mW/cm2 of ultraviolet B irradiation. A statistically significant decrease in Schiff base formation was noted between tocopherol- treated animals and their controls. Histologic study revealed a statistically significant increase in epidermal thickness in tocopherol-treated skin versus controls or vehicle alone. The thicker epidermis was accompanied by the presence of parakeratosis, implicating increased proliferation as the cause of the increasing thickness. The number of sunburn cells was decreased by tocopherol treatment. Tocopherol protection from ultraviolet irradiation may have been due to both direct protection from free radicals and indirect protection by means of increased epidermal thickness. The demonstration of beneficial effects of tocopherol administration suggests that further studies in clinically relevant models to define optimal dosage, frequency of administration, vehicle, and quantitation of the possible protective effects afforded to Langerhans cells may be useful.

Original languageEnglish (US)
Pages (from-to)973-980
Number of pages8
JournalPlastic and Reconstructive Surgery
Volume100
Issue number4
StatePublished - Sep 1 1997
Externally publishedYes

Fingerprint

Tocopherols
Ultraviolet Rays
Epidermis
Free Radicals
Ethanol
Parakeratosis
Sunburn
Skin
Langerhans Cells
Schiff Bases
Radiation Effects
Vitamin E
Reactive Oxygen Species
Cell Count

ASJC Scopus subject areas

  • Surgery

Cite this

Ritter, E. F., Axelrod, M., Minn, K. W., Eades, E., Rudner, A. M., Serafin, D., & Klitzman, B. (1997). Modulation of ultraviolet light-induced epidermal damage: Beneficial effects of tocopherol. Plastic and Reconstructive Surgery, 100(4), 973-980.

Modulation of ultraviolet light-induced epidermal damage : Beneficial effects of tocopherol. / Ritter, Edmond F; Axelrod, Mac; Minn, Kyung Won; Eades, Edward; Rudner, Adam M.; Serafin, Donald; Klitzman, Bruce.

In: Plastic and Reconstructive Surgery, Vol. 100, No. 4, 01.09.1997, p. 973-980.

Research output: Contribution to journalArticle

Ritter, EF, Axelrod, M, Minn, KW, Eades, E, Rudner, AM, Serafin, D & Klitzman, B 1997, 'Modulation of ultraviolet light-induced epidermal damage: Beneficial effects of tocopherol', Plastic and Reconstructive Surgery, vol. 100, no. 4, pp. 973-980.
Ritter EF, Axelrod M, Minn KW, Eades E, Rudner AM, Serafin D et al. Modulation of ultraviolet light-induced epidermal damage: Beneficial effects of tocopherol. Plastic and Reconstructive Surgery. 1997 Sep 1;100(4):973-980.
Ritter, Edmond F ; Axelrod, Mac ; Minn, Kyung Won ; Eades, Edward ; Rudner, Adam M. ; Serafin, Donald ; Klitzman, Bruce. / Modulation of ultraviolet light-induced epidermal damage : Beneficial effects of tocopherol. In: Plastic and Reconstructive Surgery. 1997 ; Vol. 100, No. 4. pp. 973-980.
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