Molecular aspects of arterial smooth muscle contraction: Focus on Rho

Rob H.P. Hilgers, R Clinton Webb

Research output: Contribution to journalShort survey

71 Citations (Scopus)

Abstract

The vascular smooth muscle cell is a highly specialized cell whose primary function is contraction and relaxation. It expresses a variety of contractile proteins, ion channels, and signalling molecules that regulate contraction. Upon contraction, vascular smooth muscle cells shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. Contractile activity in vascular smooth muscle cells is initiated by a Ca 2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+-sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase, thereby maintaining force. Removal of Ca 2+ from the cytosol and stimulation of myoson phosphatase initiate the relaxation of vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)829-835
Number of pages7
JournalExperimental Biology and Medicine
Volume230
Issue number11
DOIs
StatePublished - Jan 1 2005

Fingerprint

Muscle Contraction
Vascular Smooth Muscle
Smooth Muscle
Muscle
Smooth Muscle Myocytes
Contractile Proteins
Cells
Myosin-Light-Chain Phosphatase
rho-Associated Kinases
Myosin Light Chains
Phosphorylation
Blood vessels
Calmodulin
Ion Channels
Phosphoric Monoester Hydrolases
Cytosol
Blood Vessels
Blood
Blood Pressure
Molecules

Keywords

  • Calcium
  • Contraction
  • Signaling
  • Smooth muscle
  • Vascular

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Molecular aspects of arterial smooth muscle contraction : Focus on Rho. / Hilgers, Rob H.P.; Webb, R Clinton.

In: Experimental Biology and Medicine, Vol. 230, No. 11, 01.01.2005, p. 829-835.

Research output: Contribution to journalShort survey

@article{0014f7eb791448b48379db7ecadbd0a4,
title = "Molecular aspects of arterial smooth muscle contraction: Focus on Rho",
abstract = "The vascular smooth muscle cell is a highly specialized cell whose primary function is contraction and relaxation. It expresses a variety of contractile proteins, ion channels, and signalling molecules that regulate contraction. Upon contraction, vascular smooth muscle cells shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. Contractile activity in vascular smooth muscle cells is initiated by a Ca 2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+-sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase, thereby maintaining force. Removal of Ca 2+ from the cytosol and stimulation of myoson phosphatase initiate the relaxation of vascular smooth muscle.",
keywords = "Calcium, Contraction, Signaling, Smooth muscle, Vascular",
author = "Hilgers, {Rob H.P.} and Webb, {R Clinton}",
year = "2005",
month = "1",
day = "1",
doi = "10.1177/153537020523001107",
language = "English (US)",
volume = "230",
pages = "829--835",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "11",

}

TY - JOUR

T1 - Molecular aspects of arterial smooth muscle contraction

T2 - Focus on Rho

AU - Hilgers, Rob H.P.

AU - Webb, R Clinton

PY - 2005/1/1

Y1 - 2005/1/1

N2 - The vascular smooth muscle cell is a highly specialized cell whose primary function is contraction and relaxation. It expresses a variety of contractile proteins, ion channels, and signalling molecules that regulate contraction. Upon contraction, vascular smooth muscle cells shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. Contractile activity in vascular smooth muscle cells is initiated by a Ca 2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+-sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase, thereby maintaining force. Removal of Ca 2+ from the cytosol and stimulation of myoson phosphatase initiate the relaxation of vascular smooth muscle.

AB - The vascular smooth muscle cell is a highly specialized cell whose primary function is contraction and relaxation. It expresses a variety of contractile proteins, ion channels, and signalling molecules that regulate contraction. Upon contraction, vascular smooth muscle cells shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. Contractile activity in vascular smooth muscle cells is initiated by a Ca 2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+-sensitization of the contractile proteins is signaled by the RhoA/Rho-kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase, thereby maintaining force. Removal of Ca 2+ from the cytosol and stimulation of myoson phosphatase initiate the relaxation of vascular smooth muscle.

KW - Calcium

KW - Contraction

KW - Signaling

KW - Smooth muscle

KW - Vascular

UR - http://www.scopus.com/inward/record.url?scp=28944451809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28944451809&partnerID=8YFLogxK

U2 - 10.1177/153537020523001107

DO - 10.1177/153537020523001107

M3 - Short survey

C2 - 16339747

AN - SCOPUS:28944451809

VL - 230

SP - 829

EP - 835

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 11

ER -