Molecular genetics in glaucoma

Yutao Liu, R. Rand Allingham

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle-closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to glaucoma phenotypes. This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma (PCG), the developmental glaucomas, and pigment dispersion glaucoma.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalExperimental eye research
Volume93
Issue number4
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • CAV1
  • CDKN2B
  • Glaucoma
  • LOXL1
  • PCG
  • POAG
  • SIX1
  • XFG

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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