Molecular mechanisms of diabetic retinopathy: Potential therapeutic targets

Maha Coucha, Sally L. Elshaer, Wael S. Eldahshan, Barbara A. Mysona, Azza B. El-Remessy

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults in United States. Research indicates an association between oxidative stress and the development of diabetes complications. However, clinical trials with general antioxidants have failed to prove effective in diabetic patients. Mounting evidence from experimental studies that continue to elucidate the damaging effects of oxidative stress and inflammation in both vascular and neural retina suggest its critical role in the pathogenesis of DR. This review will outline the current management of DR as well as present potential experimental therapeutic interventions, focusing on molecules that link oxidative stress to inflammation to provide potential therapeutic targets for treatment or prevention of DR. Understanding the biochemical changes and the molecular events under diabetic conditions could provide new effective therapeutic tools to combat the disease.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalMiddle East African Journal of Ophthalmology
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Diabetic Retinopathy
Oxidative Stress
Inflammation
Diabetes Complications
Blindness
Therapeutics
Blood Vessels
Retina
Antioxidants
Clinical Trials
Research

Keywords

  • Diabetic retinopathy
  • Endoplasmic reticulum-stress
  • Inflammation
  • Nicotinamide adenine dinucleotide phosphate Oxidase
  • Oxidative stress
  • Peroxynitrite
  • Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Molecular mechanisms of diabetic retinopathy : Potential therapeutic targets. / Coucha, Maha; Elshaer, Sally L.; Eldahshan, Wael S.; Mysona, Barbara A.; El-Remessy, Azza B.

In: Middle East African Journal of Ophthalmology, Vol. 22, No. 2, 01.04.2015, p. 135-144.

Research output: Contribution to journalReview article

Coucha, Maha ; Elshaer, Sally L. ; Eldahshan, Wael S. ; Mysona, Barbara A. ; El-Remessy, Azza B. / Molecular mechanisms of diabetic retinopathy : Potential therapeutic targets. In: Middle East African Journal of Ophthalmology. 2015 ; Vol. 22, No. 2. pp. 135-144.
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