Molecularly confirmed primary malignant rhabdoid tumor of the urinary bladder: Implications of accurate diagnosis

Natasha Savage, Dan Linn, Colleen McDonough, Jeffrey M. Donohoe, Arie Franco, Victor Reuter, Paul W. Biddinger, Katherine W. Eaton, Jaclyn A. Biegel, Suash Sharma

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Malignant rhabdoid tumors (MRTs) are well recognized in the kidney and extrarenal sites such as soft tissues, retroperitoneum, and bladder but are classified as atypical teratoid/rhabdoid tumors in the central nervous system. The unifying features of both extracranial MRT and atypical teratoid/rhabdoid tumors are the exon deletions/mutations of the SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1) gene in 22q11.23 and resulting loss of SMARCB1/INI1 (integrase interactor 1) protein expression by immunohistochemistry. We herein report a case of extrarenal rhabdoid tumor confined to the bladder in a 3-year-old child, diagnosed by histopathology and confirmed by immunohistochemical and molecular studies. This is only the fourth molecularly proven primary MRT of the bladder to be reported. The patient's peripheral blood was negative for the deletions observed in the tumor, thereby confirming a sporadic origin for the tumor. Given the possible dismal outcome, urgency for definitive diagnosis to institute intensive multimodality therapy, histopathologic differential diagnosis with rhabdomyosarcoma and urothelial carcinoma with rhabdoid features, and lack of consensus management guidelines, oncologists, urologists, and pathologists must be aware of this entity. Evaluation for a germ line SMARCB1 alteration may greatly aid risk stratification and family planning.

Original languageEnglish (US)
Pages (from-to)504-507
Number of pages4
JournalAnnals of Diagnostic Pathology
Volume16
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • ATRT
  • Bladder
  • INI-1
  • Molecular
  • Pediatric
  • Rhabdoid tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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