Abstract
Multiple studies have demonstrated an increased risk for extra-intestinal cancers in inflammatory bowel disease (IBD) patients, mainly from treatment modalities. Prominent cancers that are related to IBD treatment include the following: lymphoproliferative disorders associated with thiopurine use, hepatosplenic T cell lymphoma primarily in younger male patients on thiopurines and anti-tumor necrosis factor (TNF) agents, non-melanoma skin cancers in patients treated with thiopurines and anti-TNF agents, and melanomas in patients who are on monotherapy with anti-TNF agents. In addition, women with IBD may have higher rates of cervical dysplasia and cervical cancer. The focus of this review is to provide a comprehensive overview on extra-intestinal cancers in IBD patients and how to monitor for these malignancies.
Original language | English (US) |
---|---|
Article number | 42 |
Journal | Current Gastroenterology Reports |
Volume | 17 |
Issue number | 11 |
DOIs | |
State | Published - Nov 22 2015 |
Keywords
- Cervical cancer
- Cervical dysplasia
- Crohn’s disease
- Extra-intestinal cancers
- Hepatosplenic T cell lymphoma
- Inflammatory bowel disease
- Lymphoma
- Lymphoproliferative disorders
- Melanoma
- Non-Hodgkin lymphoma
- Non-melanoma skin cancer
- Ulcerative colitis
ASJC Scopus subject areas
- Gastroenterology