Montelukast added to fluticasone propionate does not alter inflammation or outcomes

Ratko Djukanović, Susan J. Wilson, Wendy C. Moore, Steven M. Koenig, Michel Laviolette, Eugene R. Bleecker, W. Bruce Davis, Dennis E. Doherty, Ronald Olivenstein, Elliott Israel, Mani S. Kavuru, Eric Kleerup, Donna S. Reilly, Steven W. Yancey, Lisa D. Edwards, John L. Stauffer, Paul M. Dorinsky, Nizar N. Jarjour

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Airway inflammation is a key pathological feature of asthma which underlies its clinical presentation. Objectives: To examine whether adding a leukotriene modifier to an inhaled corticosteroid produces further clinical and/or anti-inflammatory benefits in patients symptomatic on short-acting β2-agonists. Methods: Patients uncontrolled on short-acting β2-agonists were treated for 12 weeks with either fluticasone propionate (100 mcg BD) or fluticasone propionate (100 mcg BD) and montelukast (10 mg QD) in a randomized, double-blind, parallel group study. Bronchoscopy with endobronchial biopsy and bronchoalveolar lavage (BAL) was performed before and after treatment to compare effects on airway inflammation. Results: Of 103 subjects enrolled, 89 subjects completed treatment and 82 subjects had matched pair biopsy samples. Submucosal eosinophil counts, the primary endpoint, and asthma control improved to similar extents after both treatments (p ≤ 0.008). Both treatments significantly reduced submucosal mast cell, CD3+, CD4+, CD8+ and CD25+ cell counts. Submucosal mast cell reduction was greater in the fluticasone propionate plus montelukast group. There were no differences between treatments in BAL markers of inflammation or thickness of sub-epithelial collagen. Conclusions: Low-dose fluticasone propionate significantly improves clinical disease control and reduces airway inflammation in asthma patients uncontrolled with short-acting β2-agonists without further improvement when montelukast is added to low-dose fluticasone propionate.

Original languageEnglish (US)
Pages (from-to)1425-1435
Number of pages11
JournalRespiratory Medicine
Volume104
Issue number10
DOIs
Publication statusPublished - Oct 2010

    Fingerprint

Keywords

  • Airway inflammation
  • Asthma
  • Bronchoscopy
  • Eosinophils
  • Fluticasone propionate
  • Montelukast

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Djukanović, R., Wilson, S. J., Moore, W. C., Koenig, S. M., Laviolette, M., Bleecker, E. R., ... Jarjour, N. N. (2010). Montelukast added to fluticasone propionate does not alter inflammation or outcomes. Respiratory Medicine, 104(10), 1425-1435. https://doi.org/10.1016/j.rmed.2010.04.004