Month of Birth and Risk of Immediate Hypersensitivity to Seasonal and Nonseasonal Antigens

Christine Cole Johnson, Dennis Randall Ownby, Judith Mccullough

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The risk of immediate hypersensitivity to seasonal allergens has been reported to vary with month of birth. Serum samples from 631 children less than 18 years of age from the Detroit area were measured for allergen-specific immunoglobulin E (IgE) using an enzyme-linked immunosorbent assay. IgE to the seasonal allergens ragweed, timothy, and mite were measured, as well as to the relatively nonseasonal allergens cat, dog, and Alternaria. The number of positive tests for IgE ranged from 32% for mite to 58% for cat. The birth month distribution of children with positive tests was compared to the birth month distribution of all births in the Detroit metropolitan area. Some patterns were consistent with previous studies; however, there were no statistically significant differences with respect to the comparison population. Children with positive results to ragweed tended to be born more often during the August—October ragweed season. Sensitivity to mite was most common in July and August, a time period associated with high humidity in metropolitan Detroit. Children positive for cat IgE were more often born in February, July, and November; subjects positive to dog during June—September and children positive to Alternaria peaked in July. In contrast to other studies, children with positive IgE to timothy tended to be born less often during the May—June grass season.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalPediatric Asthma, Allergy and Immunology
Volume3
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Immediate Hypersensitivity
Immunoglobulin E
Parturition
Ambrosia
Antigens
Allergens
Mites
Alternaria
Cats
Dogs
Humidity
Poaceae
Enzyme-Linked Immunosorbent Assay
Serum
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Month of Birth and Risk of Immediate Hypersensitivity to Seasonal and Nonseasonal Antigens. / Johnson, Christine Cole; Ownby, Dennis Randall; Mccullough, Judith.

In: Pediatric Asthma, Allergy and Immunology, Vol. 3, No. 3, 1989, p. 111-121.

Research output: Contribution to journalArticle

@article{ab6a04c5611a4db2af2ba0456361b8f4,
title = "Month of Birth and Risk of Immediate Hypersensitivity to Seasonal and Nonseasonal Antigens",
abstract = "The risk of immediate hypersensitivity to seasonal allergens has been reported to vary with month of birth. Serum samples from 631 children less than 18 years of age from the Detroit area were measured for allergen-specific immunoglobulin E (IgE) using an enzyme-linked immunosorbent assay. IgE to the seasonal allergens ragweed, timothy, and mite were measured, as well as to the relatively nonseasonal allergens cat, dog, and Alternaria. The number of positive tests for IgE ranged from 32{\%} for mite to 58{\%} for cat. The birth month distribution of children with positive tests was compared to the birth month distribution of all births in the Detroit metropolitan area. Some patterns were consistent with previous studies; however, there were no statistically significant differences with respect to the comparison population. Children with positive results to ragweed tended to be born more often during the August—October ragweed season. Sensitivity to mite was most common in July and August, a time period associated with high humidity in metropolitan Detroit. Children positive for cat IgE were more often born in February, July, and November; subjects positive to dog during June—September and children positive to Alternaria peaked in July. In contrast to other studies, children with positive IgE to timothy tended to be born less often during the May—June grass season.",
author = "Johnson, {Christine Cole} and Ownby, {Dennis Randall} and Judith Mccullough",
year = "1989",
doi = "10.1089/pai.1989.3.111",
language = "English (US)",
volume = "3",
pages = "111--121",
journal = "Pediatric, Allergy, Immunology, and Pulmonology",
issn = "2151-321X",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Month of Birth and Risk of Immediate Hypersensitivity to Seasonal and Nonseasonal Antigens

AU - Johnson, Christine Cole

AU - Ownby, Dennis Randall

AU - Mccullough, Judith

PY - 1989

Y1 - 1989

N2 - The risk of immediate hypersensitivity to seasonal allergens has been reported to vary with month of birth. Serum samples from 631 children less than 18 years of age from the Detroit area were measured for allergen-specific immunoglobulin E (IgE) using an enzyme-linked immunosorbent assay. IgE to the seasonal allergens ragweed, timothy, and mite were measured, as well as to the relatively nonseasonal allergens cat, dog, and Alternaria. The number of positive tests for IgE ranged from 32% for mite to 58% for cat. The birth month distribution of children with positive tests was compared to the birth month distribution of all births in the Detroit metropolitan area. Some patterns were consistent with previous studies; however, there were no statistically significant differences with respect to the comparison population. Children with positive results to ragweed tended to be born more often during the August—October ragweed season. Sensitivity to mite was most common in July and August, a time period associated with high humidity in metropolitan Detroit. Children positive for cat IgE were more often born in February, July, and November; subjects positive to dog during June—September and children positive to Alternaria peaked in July. In contrast to other studies, children with positive IgE to timothy tended to be born less often during the May—June grass season.

AB - The risk of immediate hypersensitivity to seasonal allergens has been reported to vary with month of birth. Serum samples from 631 children less than 18 years of age from the Detroit area were measured for allergen-specific immunoglobulin E (IgE) using an enzyme-linked immunosorbent assay. IgE to the seasonal allergens ragweed, timothy, and mite were measured, as well as to the relatively nonseasonal allergens cat, dog, and Alternaria. The number of positive tests for IgE ranged from 32% for mite to 58% for cat. The birth month distribution of children with positive tests was compared to the birth month distribution of all births in the Detroit metropolitan area. Some patterns were consistent with previous studies; however, there were no statistically significant differences with respect to the comparison population. Children with positive results to ragweed tended to be born more often during the August—October ragweed season. Sensitivity to mite was most common in July and August, a time period associated with high humidity in metropolitan Detroit. Children positive for cat IgE were more often born in February, July, and November; subjects positive to dog during June—September and children positive to Alternaria peaked in July. In contrast to other studies, children with positive IgE to timothy tended to be born less often during the May—June grass season.

UR - http://www.scopus.com/inward/record.url?scp=85012516495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012516495&partnerID=8YFLogxK

U2 - 10.1089/pai.1989.3.111

DO - 10.1089/pai.1989.3.111

M3 - Article

AN - SCOPUS:85012516495

VL - 3

SP - 111

EP - 121

JO - Pediatric, Allergy, Immunology, and Pulmonology

JF - Pediatric, Allergy, Immunology, and Pulmonology

SN - 2151-321X

IS - 3

ER -