Morphological and smooth muscle cell phenotypic changes in fetal rabbit aorta during early development

A. J. Cayatte, Muhammad Ashraf, M. T.R. Subbiah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous studies from our laboratory noted a) high aortic cholesterol esterification activity in the fetal rabbit, and b) increased susceptibility of fetal aortic explants to smooth muscle cell proliferation in culture, two features commonly associated with atherogenesis. This prompted us to examine in detail morphological development of fetal aorta and its relationship to fetal plasma cholesterol levels. Our studies made three important observations: 1) plasma cholesterol levels were high in early fetus which decreased at term; 2) in early fetus aortic endothelial cells appear to protrude into the lumen, whereas at birth the cells become flat, forming a continuous endothelium sheet; 3) in early fetus, smooth muscle cells exist predominantly in synthetic phenotype, while at birth the cells appear contractile. Despite the presence of synthetic smooth muscle cells and hypercholesterolemia in early fetal life, no accumulation of lipids was evident under transmission electron microscopy.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalBasic Research in Cardiology
Volume84
Issue number3
DOIs
StatePublished - May 1 1989
Externally publishedYes

Fingerprint

Smooth Muscle Myocytes
Aorta
Fetus
Rabbits
Hypercholesterolemia
Cholesterol
Parturition
Fetal Movement
Esterification
Fetal Development
Transmission Electron Microscopy
Endothelium
Atherosclerosis
Endothelial Cells
Cell Proliferation
Phenotype
Lipids

Keywords

  • endothelium
  • fetal rabbit aorta
  • hypercholesterolemia
  • plasma cholesterol
  • smooth muscle cell
  • transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Morphological and smooth muscle cell phenotypic changes in fetal rabbit aorta during early development. / Cayatte, A. J.; Ashraf, Muhammad; Subbiah, M. T.R.

In: Basic Research in Cardiology, Vol. 84, No. 3, 01.05.1989, p. 259-267.

Research output: Contribution to journalArticle

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