Morphological and smooth muscle cell phenotypic changes in fetal rabbit aorta during early development

A. J. Cayatte, M. Ashraf, M. T.R. Subbiah

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Previous studies from our laboratory noted a) high aortic cholesterol esterification activity in the fetal rabbit, and b) increased susceptibility of fetal aortic explants to smooth muscle cell proliferation in culture, two features commonly associated with atherogenesis. This prompted us to examine in detail morphological development of fetal aorta and its relationship to fetal plasma cholesterol levels. Our studies made three important observations: 1) plasma cholesterol levels were high in early fetus which decreased at term; 2) in early fetus aortic endothelial cells appear to protrude into the lumen, whereas at birth the cells become flat, forming a continuous endothelium sheet; 3) in early fetus, smooth muscle cells exist predominantly in synthetic phenotype, while at birth the cells appear contractile. Despite the presence of synthetic smooth muscle cells and hypercholesterolemia in early fetal life, no accumulation of lipids was evident under transmission electron microscopy.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalBasic Research in Cardiology
Volume84
Issue number3
DOIs
StatePublished - May 1989
Externally publishedYes

Keywords

  • endothelium
  • fetal rabbit aorta
  • hypercholesterolemia
  • plasma cholesterol
  • smooth muscle cell
  • transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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