Morphological control of mitochondrial bioenergetics

Tianzheng Yu, Li Wang, Yisang Yoon

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The major function of mitochondria is production and supply of cellular energy. Mitochondria are highly dynamic organelles undergoing frequent shape changes via fission and fusion. Many studies have elucidated the molecular components mediating fission and fusion and their regulatory mechanisms, and mitochondrial shape change is now recognized as an essential cellular process that is closely associated with functional states of mitochondria. This review updates the recent advancements in fission and fusion mechanisms, and discusses the bi-directional relationship between mitochondrial morphology and energetic states in physio-pathological settings.

Original languageEnglish (US)
Pages (from-to)229-246
Number of pages18
JournalFrontiers in Bioscience - Landmark
Volume20
Issue number2
DOIs
StatePublished - Jan 15 2015

Keywords

  • Bioenergetics
  • DLP1
  • Drp1
  • Dynamics
  • Fission
  • Fusion
  • Mfn
  • Mitochondria
  • Morphology
  • OPA1
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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