TY - JOUR
T1 - Multi-Centre Comparison of Abbott Matrix® Aero™ to Pharmacia Standard Rast®, Modified Rast and Skin Puncture Tests
AU - Ownby, Dennis Randall
AU - Hamilton, R. G.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - ABBOTT MATRIX® Aero™ is an enzyme immunoassay which measures specific IgE antibodies to 14 individually calibräted airborne allergens using a single serum specimen. In this study, ABBOTT MATRIX performance was evaluated in comparison to the results of skin puncture test and the Standard and Modified RAST® procedures. The ABBOTT MATRIX demonstrated overall sensitivity of 89% vs. Standard RAST and Modified RAST, with specificity greater than 92% vs. both methods. ABBOTT MATRIX sensitivity vs. skin test (71%) exceeded that of the Standard and Modified RAST procedures (62% and 67% respectively). Positive results reported by ABBOTT MATRIX but not RAST were corroborated by skin test results for 3 of 5 allergens evaluated. All in vitro Systems demonstrated specificity of approximately 90% vs. skin test. The ABBOTT MATRIX System provided results which compared favoräbly with the results of skin test and RAST, but required less hands-on time to obtain quantitative specific IgE measurements to multiple allergens.
AB - ABBOTT MATRIX® Aero™ is an enzyme immunoassay which measures specific IgE antibodies to 14 individually calibräted airborne allergens using a single serum specimen. In this study, ABBOTT MATRIX performance was evaluated in comparison to the results of skin puncture test and the Standard and Modified RAST® procedures. The ABBOTT MATRIX demonstrated overall sensitivity of 89% vs. Standard RAST and Modified RAST, with specificity greater than 92% vs. both methods. ABBOTT MATRIX sensitivity vs. skin test (71%) exceeded that of the Standard and Modified RAST procedures (62% and 67% respectively). Positive results reported by ABBOTT MATRIX but not RAST were corroborated by skin test results for 3 of 5 allergens evaluated. All in vitro Systems demonstrated specificity of approximately 90% vs. skin test. The ABBOTT MATRIX System provided results which compared favoräbly with the results of skin test and RAST, but required less hands-on time to obtain quantitative specific IgE measurements to multiple allergens.
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U2 - 10.1515/cclm.1994.32.8.631
DO - 10.1515/cclm.1994.32.8.631
M3 - Article
C2 - 7819435
SN - 1434-6621
VL - 32
SP - 631
EP - 638
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 8
ER -