Multiphase intrafibrillar mineralization of collagen

Li Na Niu; Kai Jiao; Heonjune Ryou; Cynthia K.Y. Yiu; Ji Hua Chen; Lorenzo Breschi; Dwayne D. Arola; David H. Pashley; Franklin R. Tay

doi:10.1002/anie.201210259

Multiphase intrafibrillar mineralization of collagen

Li Na Niu, Kai Jiao, Heonjune Ryou, Cynthia K.Y. Yiu, Ji Hua Chen, Lorenzo Breschi, Dwayne D. Arola, David H. Pashley, Franklin R. Tay

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.

Original language	English (US)
Pages (from-to)	5762-5766
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	22
DOIs	https://doi.org/10.1002/anie.201210259
State	Published - May 27 2013

Keywords

biomineralization
calcification
crystal growth
fibrous proteins
silicification

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201210259

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abstract = "Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.",

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T1 - Multiphase intrafibrillar mineralization of collagen

AU - Niu, Li Na

AU - Jiao, Kai

AU - Ryou, Heonjune

AU - Yiu, Cynthia K.Y.

AU - Chen, Ji Hua

AU - Breschi, Lorenzo

AU - Arola, Dwayne D.

AU - Pashley, David H.

AU - Tay, Franklin R.

PY - 2013/5/27

Y1 - 2013/5/27

N2 - Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.

AB - Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.

KW - biomineralization

KW - calcification

KW - crystal growth

KW - fibrous proteins

KW - silicification

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JF - Angewandte Chemie - International Edition

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Multiphase intrafibrillar mineralization of collagen

Abstract

Keywords

ASJC Scopus subject areas

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