Multiphase intrafibrillar mineralization of collagen

Li Na Niu, Kai Jiao, Heonjune Ryou, Cynthia K.Y. Yiu, Ji Hua Chen, Lorenzo Breschi, Dwayne D. Arola, David H. Pashley, Franklin R. Tay

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.

Original languageEnglish (US)
Pages (from-to)5762-5766
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number22
DOIs
StatePublished - May 27 2013

Fingerprint

Collagen
Silicic Acid
Biomineralization
Apatites
Apatite
Calcium phosphate
Crystallites
Silicon Dioxide
Silica
Acids
Composite materials

Keywords

  • biomineralization
  • calcification
  • crystal growth
  • fibrous proteins
  • silicification

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Niu, L. N., Jiao, K., Ryou, H., Yiu, C. K. Y., Chen, J. H., Breschi, L., ... Tay, F. R. (2013). Multiphase intrafibrillar mineralization of collagen. Angewandte Chemie - International Edition, 52(22), 5762-5766. https://doi.org/10.1002/anie.201210259

Multiphase intrafibrillar mineralization of collagen. / Niu, Li Na; Jiao, Kai; Ryou, Heonjune; Yiu, Cynthia K.Y.; Chen, Ji Hua; Breschi, Lorenzo; Arola, Dwayne D.; Pashley, David H.; Tay, Franklin R.

In: Angewandte Chemie - International Edition, Vol. 52, No. 22, 27.05.2013, p. 5762-5766.

Research output: Contribution to journalArticle

Niu, LN, Jiao, K, Ryou, H, Yiu, CKY, Chen, JH, Breschi, L, Arola, DD, Pashley, DH & Tay, FR 2013, 'Multiphase intrafibrillar mineralization of collagen', Angewandte Chemie - International Edition, vol. 52, no. 22, pp. 5762-5766. https://doi.org/10.1002/anie.201210259
Niu LN, Jiao K, Ryou H, Yiu CKY, Chen JH, Breschi L et al. Multiphase intrafibrillar mineralization of collagen. Angewandte Chemie - International Edition. 2013 May 27;52(22):5762-5766. https://doi.org/10.1002/anie.201210259
Niu, Li Na ; Jiao, Kai ; Ryou, Heonjune ; Yiu, Cynthia K.Y. ; Chen, Ji Hua ; Breschi, Lorenzo ; Arola, Dwayne D. ; Pashley, David H. ; Tay, Franklin R. / Multiphase intrafibrillar mineralization of collagen. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 22. pp. 5762-5766.
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