Multiphase intrafibrillar mineralization of collagen

Li Na Niu, Kai Jiao, Heonjune Ryou, Cynthia K.Y. Yiu, Ji Hua Chen, Lorenzo Breschi, Dwayne D. Arola, David H. Pashley, Franklin R. Tay

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.

Original languageEnglish (US)
Pages (from-to)5762-5766
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number22
StatePublished - May 27 2013


  • biomineralization
  • calcification
  • crystal growth
  • fibrous proteins
  • silicification

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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