Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei

STEFAN MAGEZ, Rudolf Lucas, AYUB DARJI, EMMANUEL BAJYANA SONGA, RAYMOND HAMERS, PATRICK DE BAETSELIER

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Soluble extracts from salivarian trypanosomes (Trypanosoma brucei brucei, T. evansi and T. congolense) were shown to be capable of inducing murine tumour necrosis factor (mTNF) secretion, both in vivo and in vitro, whereas the soluble extract of an intracellular trypanosome (T. cruzi) failed to do so. Furthermore, the role of mTNF during the initial phase of experimental infections with T. brucei was studied by treating infected mice with mTNF‐inducing trypanosoma soluble extract and with neutralizing monoclonal anti‐mTNF antibodies. Treatment of the infected animals with different doses of T. brucei soluble extract resulted in a lower first parasitaemia peak (low lysate dose) and in a longer survival time or in a nearly total inhibition of parasite development (high lysate dose). Cotreatment of the infected mice with both anti‐mTNF antibodies and a high dose of soluble extract completely restored the parasite development in both trypanosusceptible C3H/He mice and trypanosubtolerant CBA/Ca mice, indicating a protective role of mTNF during the parasitaemia. Collectively these results suggest a negative influence of mTNF on T. brucei development in vivo.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalParasite Immunology
Volume15
Issue number11
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Trypanosoma brucei brucei
Tumor Necrosis Factor-alpha
Parasitemia
Trypanosomiasis
Infection
Parasites
Trypanosoma
Inbred CBA Mouse
Inbred C3H Mouse
Neutralizing Antibodies
Monoclonal Antibodies
Antibodies

Keywords

  • T. brucei
  • TNF

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei. / MAGEZ, STEFAN; Lucas, Rudolf; DARJI, AYUB; SONGA, EMMANUEL BAJYANA; HAMERS, RAYMOND; BAETSELIER, PATRICK DE.

In: Parasite Immunology, Vol. 15, No. 11, 01.01.1993, p. 635-641.

Research output: Contribution to journalArticle

MAGEZ, STEFAN ; Lucas, Rudolf ; DARJI, AYUB ; SONGA, EMMANUEL BAJYANA ; HAMERS, RAYMOND ; BAETSELIER, PATRICK DE. / Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei. In: Parasite Immunology. 1993 ; Vol. 15, No. 11. pp. 635-641.
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