Myasthenia gravis immunoglobulin augments motor neuron survival without producing muscle paralysis

G. S. Sohal, Robert T. Leshner, Thomas Robert Swift

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effects of sera or immunoglobulins from patients with acquired myasthenia gravis on motor neuron survival during critical stages of embryonic development were investigated in the trochlear nucleus–superior oblique muscle system of white Peking duck embryos. A significant increase in motor neuron survival occurred following application of myasthenia gravis sera or myasthenic immunoglobulin during the period of embryonic death of motor neurons. There was no reduction in limb or extraocular muscle movement in treated embryos. Trochlear motor neuron survival persisted after sera or immunoglobulin treatment was discontinued. The total number of muscle fibers and acetylcholine receptros were unchanged following immunoglobulin treatment. Myasthenic immunoglobulin is therefore unique in preventing motor neuron death without producing muscle paralysis and in promoting a prolonged augmentation of motor neuron survival. It is concluded that factors other than muscle activity may also control neuron survival during embryogenesis. Previous studies of myasthenic sera in muscle have shown effects only postsynaptically. This is the first demonstration that myasthenic immunoglobulin affects structures in the central nervous system.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalMuscle & nerve
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1983

Fingerprint

Myasthenia Gravis
Motor Neurons
Paralysis
Immunoglobulins
Muscle Weakness
Muscles
Serum
Embryonic Development
Oculomotor Muscles
Embryonic Structures
Ducks
Acetylcholine
Extremities
Central Nervous System
Neurons
Therapeutics

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Myasthenia gravis immunoglobulin augments motor neuron survival without producing muscle paralysis. / Sohal, G. S.; Leshner, Robert T.; Swift, Thomas Robert.

In: Muscle & nerve, Vol. 6, No. 2, 01.01.1983, p. 122-127.

Research output: Contribution to journalArticle

@article{7a34d8004ef544d49d6debb559eb4e1f,
title = "Myasthenia gravis immunoglobulin augments motor neuron survival without producing muscle paralysis",
abstract = "Effects of sera or immunoglobulins from patients with acquired myasthenia gravis on motor neuron survival during critical stages of embryonic development were investigated in the trochlear nucleus–superior oblique muscle system of white Peking duck embryos. A significant increase in motor neuron survival occurred following application of myasthenia gravis sera or myasthenic immunoglobulin during the period of embryonic death of motor neurons. There was no reduction in limb or extraocular muscle movement in treated embryos. Trochlear motor neuron survival persisted after sera or immunoglobulin treatment was discontinued. The total number of muscle fibers and acetylcholine receptros were unchanged following immunoglobulin treatment. Myasthenic immunoglobulin is therefore unique in preventing motor neuron death without producing muscle paralysis and in promoting a prolonged augmentation of motor neuron survival. It is concluded that factors other than muscle activity may also control neuron survival during embryogenesis. Previous studies of myasthenic sera in muscle have shown effects only postsynaptically. This is the first demonstration that myasthenic immunoglobulin affects structures in the central nervous system.",
author = "Sohal, {G. S.} and Leshner, {Robert T.} and Swift, {Thomas Robert}",
year = "1983",
month = "1",
day = "1",
doi = "10.1002/mus.880060207",
language = "English (US)",
volume = "6",
pages = "122--127",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Myasthenia gravis immunoglobulin augments motor neuron survival without producing muscle paralysis

AU - Sohal, G. S.

AU - Leshner, Robert T.

AU - Swift, Thomas Robert

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Effects of sera or immunoglobulins from patients with acquired myasthenia gravis on motor neuron survival during critical stages of embryonic development were investigated in the trochlear nucleus–superior oblique muscle system of white Peking duck embryos. A significant increase in motor neuron survival occurred following application of myasthenia gravis sera or myasthenic immunoglobulin during the period of embryonic death of motor neurons. There was no reduction in limb or extraocular muscle movement in treated embryos. Trochlear motor neuron survival persisted after sera or immunoglobulin treatment was discontinued. The total number of muscle fibers and acetylcholine receptros were unchanged following immunoglobulin treatment. Myasthenic immunoglobulin is therefore unique in preventing motor neuron death without producing muscle paralysis and in promoting a prolonged augmentation of motor neuron survival. It is concluded that factors other than muscle activity may also control neuron survival during embryogenesis. Previous studies of myasthenic sera in muscle have shown effects only postsynaptically. This is the first demonstration that myasthenic immunoglobulin affects structures in the central nervous system.

AB - Effects of sera or immunoglobulins from patients with acquired myasthenia gravis on motor neuron survival during critical stages of embryonic development were investigated in the trochlear nucleus–superior oblique muscle system of white Peking duck embryos. A significant increase in motor neuron survival occurred following application of myasthenia gravis sera or myasthenic immunoglobulin during the period of embryonic death of motor neurons. There was no reduction in limb or extraocular muscle movement in treated embryos. Trochlear motor neuron survival persisted after sera or immunoglobulin treatment was discontinued. The total number of muscle fibers and acetylcholine receptros were unchanged following immunoglobulin treatment. Myasthenic immunoglobulin is therefore unique in preventing motor neuron death without producing muscle paralysis and in promoting a prolonged augmentation of motor neuron survival. It is concluded that factors other than muscle activity may also control neuron survival during embryogenesis. Previous studies of myasthenic sera in muscle have shown effects only postsynaptically. This is the first demonstration that myasthenic immunoglobulin affects structures in the central nervous system.

UR - http://www.scopus.com/inward/record.url?scp=0020527258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020527258&partnerID=8YFLogxK

U2 - 10.1002/mus.880060207

DO - 10.1002/mus.880060207

M3 - Article

C2 - 6855796

AN - SCOPUS:0020527258

VL - 6

SP - 122

EP - 127

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 2

ER -