Abstract
MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 301-309 |
| Number of pages | 9 |
| Journal | Nature Reviews Cancer |
| Volume | 10 |
| Issue number | 4 |
| DOIs |
|
| State | Published - Apr 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
MYC as a regulator of ribosome biogenesis and protein synthesis. / Van Riggelen, Jan; Yetil, Alper; Felsher, Dean W.
In: Nature Reviews Cancer, Vol. 10, No. 4, 01.04.2010, p. 301-309.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - MYC as a regulator of ribosome biogenesis and protein synthesis
AU - Van Riggelen, Jan
AU - Yetil, Alper
AU - Felsher, Dean W.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.
AB - MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.
UR - http://www.scopus.com/inward/record.url?scp=77949920493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949920493&partnerID=8YFLogxK
U2 - 10.1038/nrc2819
DO - 10.1038/nrc2819
M3 - Comment/debate
VL - 10
SP - 301
EP - 309
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 4
ER -