MYC as a regulator of ribosome biogenesis and protein synthesis

Jan Van Riggelen; Alper Yetil; Dean W. Felsher

doi:10.1038/nrc2819

MYC as a regulator of ribosome biogenesis and protein synthesis

Jan Van Riggelen, Alper Yetil, Dean W. Felsher

Biochemistry and Molecular Biology

Research output: Contribution to journal › Comment/debate

391 Citations (Scopus)

Abstract

MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Nature Reviews Cancer
Volume	10
Issue number	4
DOIs	https://doi.org/10.1038/nrc2819
State	Published - Apr 1 2010

Fingerprint

Ribosomes

Gene Components

Ribosome Subunits

Proteins

Ribosomal RNA

Cell Nucleus Active Transport

Protein Biosynthesis

Carcinogenesis

RNA

Apoptosis

Growth

Genes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Van Riggelen, J., Yetil, A., & Felsher, D. W. (2010). MYC as a regulator of ribosome biogenesis and protein synthesis. Nature Reviews Cancer, 10(4), 301-309. https://doi.org/10.1038/nrc2819

MYC as a regulator of ribosome biogenesis and protein synthesis. / Van Riggelen, Jan; Yetil, Alper; Felsher, Dean W.

In: Nature Reviews Cancer, Vol. 10, No. 4, 01.04.2010, p. 301-309.

Research output: Contribution to journal › Comment/debate

Van Riggelen, J, Yetil, A & Felsher, DW 2010, 'MYC as a regulator of ribosome biogenesis and protein synthesis', Nature Reviews Cancer, vol. 10, no. 4, pp. 301-309. https://doi.org/10.1038/nrc2819

Van Riggelen J, Yetil A, Felsher DW. MYC as a regulator of ribosome biogenesis and protein synthesis. Nature Reviews Cancer. 2010 Apr 1;10(4):301-309. https://doi.org/10.1038/nrc2819

Van Riggelen, Jan ; Yetil, Alper ; Felsher, Dean W. / MYC as a regulator of ribosome biogenesis and protein synthesis. In: Nature Reviews Cancer. 2010 ; Vol. 10, No. 4. pp. 301-309.

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