MYC as a regulator of ribosome biogenesis and protein synthesis

Jan Van Riggelen, Alper Yetil, Dean W. Felsher

Research output: Contribution to journalComment/debate

440 Scopus citations

Abstract

MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalNature Reviews Cancer
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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