Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX

Afshin Ameri, Sumiko Kurachi, Katsuo Sueishi, Mitsuhiro Kuwahara, Kotoku Kurachi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice overexpressing human factor IX at persistently high levels died at much younger ages than their cohorts expressing lower levels, or nontransgenic control animals. The median survival age of animals was inversely related to the circulatory levels of human factor IX. Prematurely dying animals had focal fibrotic lesions predominantly present in the left ventricular myocardium, and vasculatures in these lesions showed fibrin deposition. Thromboemboli were also present in other organs, including lung and brain. These observations support the hypothesis that persistently high circulatory levels of factor IX are a risk factor not only for thrombosis and/or thromboembolism, but also for myocardial fibrosis mimicking human myocardial infarction.

Original languageEnglish (US)
Pages (from-to)1871-1873
Number of pages3
JournalBlood
Volume101
Issue number5
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Factor IX
Fibrosis
Animals
Human engineering
Thrombosis
Blood Coagulation Factors
Thromboembolism
Fibrin
Venous Thrombosis
Transgenic Mice
Brain
Myocardium
Demonstrations
Myocardial Infarction
Lung
Survival

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX. / Ameri, Afshin; Kurachi, Sumiko; Sueishi, Katsuo; Kuwahara, Mitsuhiro; Kurachi, Kotoku.

In: Blood, Vol. 101, No. 5, 01.03.2003, p. 1871-1873.

Research output: Contribution to journalArticle

Ameri, A, Kurachi, S, Sueishi, K, Kuwahara, M & Kurachi, K 2003, 'Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX', Blood, vol. 101, no. 5, pp. 1871-1873. https://doi.org/10.1182/blood-2002-05-1581
Ameri, Afshin ; Kurachi, Sumiko ; Sueishi, Katsuo ; Kuwahara, Mitsuhiro ; Kurachi, Kotoku. / Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX. In: Blood. 2003 ; Vol. 101, No. 5. pp. 1871-1873.
@article{c2e4a473be064395a7571c0f7e77b65d,
title = "Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX",
abstract = "Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice overexpressing human factor IX at persistently high levels died at much younger ages than their cohorts expressing lower levels, or nontransgenic control animals. The median survival age of animals was inversely related to the circulatory levels of human factor IX. Prematurely dying animals had focal fibrotic lesions predominantly present in the left ventricular myocardium, and vasculatures in these lesions showed fibrin deposition. Thromboemboli were also present in other organs, including lung and brain. These observations support the hypothesis that persistently high circulatory levels of factor IX are a risk factor not only for thrombosis and/or thromboembolism, but also for myocardial fibrosis mimicking human myocardial infarction.",
author = "Afshin Ameri and Sumiko Kurachi and Katsuo Sueishi and Mitsuhiro Kuwahara and Kotoku Kurachi",
year = "2003",
month = "3",
day = "1",
doi = "10.1182/blood-2002-05-1581",
language = "English (US)",
volume = "101",
pages = "1871--1873",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "5",

}

TY - JOUR

T1 - Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX

AU - Ameri, Afshin

AU - Kurachi, Sumiko

AU - Sueishi, Katsuo

AU - Kuwahara, Mitsuhiro

AU - Kurachi, Kotoku

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice overexpressing human factor IX at persistently high levels died at much younger ages than their cohorts expressing lower levels, or nontransgenic control animals. The median survival age of animals was inversely related to the circulatory levels of human factor IX. Prematurely dying animals had focal fibrotic lesions predominantly present in the left ventricular myocardium, and vasculatures in these lesions showed fibrin deposition. Thromboemboli were also present in other organs, including lung and brain. These observations support the hypothesis that persistently high circulatory levels of factor IX are a risk factor not only for thrombosis and/or thromboembolism, but also for myocardial fibrosis mimicking human myocardial infarction.

AB - Elevated circulatory levels of many blood coagulation factors are known to be a risk factor for deep vein thrombosis in humans. Here we report the first direct demonstration of a close association between elevated circulatory factor IX levels in mice with thrombosis as well as myocardial fibrosis. Transgenic mice overexpressing human factor IX at persistently high levels died at much younger ages than their cohorts expressing lower levels, or nontransgenic control animals. The median survival age of animals was inversely related to the circulatory levels of human factor IX. Prematurely dying animals had focal fibrotic lesions predominantly present in the left ventricular myocardium, and vasculatures in these lesions showed fibrin deposition. Thromboemboli were also present in other organs, including lung and brain. These observations support the hypothesis that persistently high circulatory levels of factor IX are a risk factor not only for thrombosis and/or thromboembolism, but also for myocardial fibrosis mimicking human myocardial infarction.

UR - http://www.scopus.com/inward/record.url?scp=0037369261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037369261&partnerID=8YFLogxK

U2 - 10.1182/blood-2002-05-1581

DO - 10.1182/blood-2002-05-1581

M3 - Article

C2 - 12406910

AN - SCOPUS:0037369261

VL - 101

SP - 1871

EP - 1873

JO - Blood

JF - Blood

SN - 0006-4971

IS - 5

ER -