NAD(P)H oxidase: Role in cardiovascular biology and disease

Kathy K. Griendling, Dan Sorescu, Masuko Ushio-Fukai

Research output: Contribution to journalShort survey

2439 Scopus citations

Abstract

Reactive oxygen species have emerged as important molecules in cardiovascular function. Recent work has shown that NAD(P)H oxidases are major sources of superoxide in vascular cells and myocytes. The biochemical characterization, activation paradigms, structure, and function of this enzyme are now partly understood. Vascular NAD(P)H oxidases share some, but not all, characteristics of the neutrophil enzyme. In response to growth factors and cytokines, they produce superoxide, which is metabolized to hydrogen peroxide, and both of these reactive oxygen species serve as second messengers to activate multiple intracellular signaling pathways. The vascular NAD(P)H oxidases have been found to be essential in the physiological response of vascular cells, including growth, migration, and modification of the extracellular matrix. They have also been linked to hypertension and to pathological states associated with uncontrolled growth and inflammation, such as atherosclerosis.

Original languageEnglish (US)
Pages (from-to)494-501
Number of pages8
JournalCirculation research
Volume86
Issue number5
DOIs
StatePublished - Mar 17 2000
Externally publishedYes

Keywords

  • NAD(P)H oxidase
  • Reactive oxygen species
  • Superoxide
  • Vascular cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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