Negative Regulators of Brown Adipose Tissue (BAT)-Mediated Thermogenesis

Bal Krishan Sharma, Mallikarjun Patil, Satyanarayana Ande

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. PET-CT scans recently demonstrated the existence of metabolically active BAT in adult humans, which revitalized our interest in BAT. Increasing the amount and/or activity of BAT holds tremendous promise for the treatment of obesity and its associated diseases. PGC1α is the master regulator of UCP1-mediated thermogenesis in BAT. A number of proteins have been identified to influence thermogenesis either positively or negatively through regulating the expression or transcriptional activity of PGC1α. Therefore, BAT activation can be achieved by either inducing the expression of positive regulators of PGC1α or by inhibiting the repressors of the PGC1α/UCP1 pathway. Here, we review the most important negative regulators of PGC1α/UCP1 signaling and their mechanism of action in BAT-mediated thermogenesis.

Original languageEnglish (US)
Pages (from-to)1901-1907
Number of pages7
JournalJournal of Cellular Physiology
Issue number12
StatePublished - Dec 2014

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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