Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses

Hongbing Guan, Guorui Zu, Yi Xie, Hao Tang, Martin Johnson, Xiaochun Xu, Christophe Kevil, Wencheng Xiong, Craig Elmets, Yi Rao, Jane Y. Wu, Hui Xu

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

One of the essential functions of dendritic cells is to take up Ags in peripheral tissues and migrate into secondary lymphoid organs to present Ags to lymphocytes for the induction of immune responses. Although many studies have demonstrated that the migration of dendritic cells is closely associated with the development of immune responses, little is known about factors that inhibit dendritic cell migration and control the extent of immune responses to Ag stimulation. We show that Slit2, a neuronal repellent factor, is up-regulated in the skin by allergen sensitization and down-regulates the migration of Langerhans cells. The effect is mediated by direct interaction of Slit2 with cells that express a Slit-specific receptor, Robo1. Slit2-mediated inhibition of Langerhans cell migration results in suppression of contact hypersensitivity responses. These findings provide insights into a novel mechanism by which Slit2 functions as an anti-inflammatory factor for the initiation of immune responses.

Original languageEnglish (US)
Pages (from-to)6519-6526
Number of pages8
JournalJournal of Immunology
Volume171
Issue number12
DOIs
StatePublished - Dec 15 2003

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Dendritic Cells
Cell Movement
Langerhans Cells
Peptide Initiation Factors
Contact Dermatitis
Immunologic Factors
Allergens
Anti-Inflammatory Agents
Down-Regulation
Lymphocytes
Skin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses. / Guan, Hongbing; Zu, Guorui; Xie, Yi; Tang, Hao; Johnson, Martin; Xu, Xiaochun; Kevil, Christophe; Xiong, Wencheng; Elmets, Craig; Rao, Yi; Wu, Jane Y.; Xu, Hui.

In: Journal of Immunology, Vol. 171, No. 12, 15.12.2003, p. 6519-6526.

Research output: Contribution to journalArticle

Guan, H, Zu, G, Xie, Y, Tang, H, Johnson, M, Xu, X, Kevil, C, Xiong, W, Elmets, C, Rao, Y, Wu, JY & Xu, H 2003, 'Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses', Journal of Immunology, vol. 171, no. 12, pp. 6519-6526. https://doi.org/10.4049/jimmunol.171.12.6519
Guan, Hongbing ; Zu, Guorui ; Xie, Yi ; Tang, Hao ; Johnson, Martin ; Xu, Xiaochun ; Kevil, Christophe ; Xiong, Wencheng ; Elmets, Craig ; Rao, Yi ; Wu, Jane Y. ; Xu, Hui. / Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses. In: Journal of Immunology. 2003 ; Vol. 171, No. 12. pp. 6519-6526.
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