Neuropathy and IgM paraproteinemia: Differential binding of IgM M-proteins to peripheral nerve glycolipids

S. Kusunoki, T. Kohriyama, A. R. Pachner, N. Latov, R. K. Yu

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Two patients with neuropathy and IgM paraproteinemia displayed different immunoreactivity to acidic peripheral nerve glycolipids: In one patient, immunostaining on thin-layer chromatographic plate revealed binding of the IgM to sulfated glucuronosyl paragloboside (SGPG) and sulfated glucuronosyl lactosaminyl paragloboside (SGLPG). The other IgM bound SGPG, SGLPG, and a new third glycolipid. Immunoreactivity of the IgM varies in this syndrome.

Original languageEnglish (US)
Pages (from-to)1795-1797
Number of pages3
JournalNeurology
Volume37
Issue number11
DOIs
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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