Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease

Laura H. Lacritz, C. Munro Cullum, Alan B. Frol, Richard B. Dewey, Cole A. Giller

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Neuropsychological functioning was examined at baseline and 2- to 3- month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fluency at follow-up. Right pallidotomy was associated with decreased cognitive flexibility and increased verbal fluency, whereas Left pallidotomy uniquely resulted in a decline in verbal fluency. Significant motor improvement was demonstrated in both groups. Pallidotomy appears to be an effective treatment for advanced PD, providing a significant improvement in motor functioning, while resulting in few deleterious neurocognitive changes in most cases. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)364-378
Number of pages15
JournalBrain and Cognition
Volume42
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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Pallidotomy
Parkinson Disease
Verbal Learning
Parkinson's Disease
Verbal Fluency

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Cite this

Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease. / Lacritz, Laura H.; Cullum, C. Munro; Frol, Alan B.; Dewey, Richard B.; Giller, Cole A.

In: Brain and Cognition, Vol. 42, No. 3, 01.01.2000, p. 364-378.

Research output: Contribution to journalArticle

Lacritz, Laura H. ; Cullum, C. Munro ; Frol, Alan B. ; Dewey, Richard B. ; Giller, Cole A. / Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease. In: Brain and Cognition. 2000 ; Vol. 42, No. 3. pp. 364-378.
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