Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

J. H. Gilmore; L. F. Jarskog; J. C. Lindgren; J. P. McEvoy; H. Xiao

doi:10.1016/S0165-1781(97)00116-9

Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

J. H. Gilmore, L. F. Jarskog, J. C. Lindgren, J. P. McEvoy, H. Xiao

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

Original language	English (US)
Pages (from-to)	109-113
Number of pages	5
Journal	Psychiatry Research
Volume	73
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-1781(97)00116-9
State	Published - Nov 14 1997
Externally published	Yes

Keywords

CNS infection
Hydrocephalus
Meningitis
Neurotrophic factors

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-1781(97)00116-9

Cite this

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abstract = "Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.",

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AU - Gilmore, J. H.

AU - Jarskog, L. F.

AU - Lindgren, J. C.

AU - McEvoy, J. P.

AU - Xiao, H.

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AB - Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

KW - CNS infection

KW - Hydrocephalus

KW - Meningitis

KW - Neurotrophic factors

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Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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