Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

J. H. Gilmore, L. F. Jarskog, J. C. Lindgren, J. P. McEvoy, H. Xiao

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Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalPsychiatry Research
Issue number1-2
StatePublished - Nov 14 1997
Externally publishedYes



  • CNS infection
  • Hydrocephalus
  • Meningitis
  • Neurotrophic factors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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