Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

J. H. Gilmore, L. F. Jarskog, J. C. Lindgren, Joseph Patrick McEvoy, H. Xiao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme- linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalPsychiatry Research
Volume73
Issue number1-2
DOIs
StatePublished - Nov 14 1997

Fingerprint

Neurotrophin 3
Cerebrospinal Fluid
Schizophrenia
Central Nervous System Infections
Hydrocephalus
Enzyme-Linked Immunosorbent Assay
Genes
Proteins

Keywords

  • CNS infection
  • Hydrocephalus
  • Meningitis
  • Neurotrophic factors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness. / Gilmore, J. H.; Jarskog, L. F.; Lindgren, J. C.; McEvoy, Joseph Patrick; Xiao, H.

In: Psychiatry Research, Vol. 73, No. 1-2, 14.11.1997, p. 109-113.

Research output: Contribution to journalArticle

Gilmore, J. H. ; Jarskog, L. F. ; Lindgren, J. C. ; McEvoy, Joseph Patrick ; Xiao, H. / Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness. In: Psychiatry Research. 1997 ; Vol. 73, No. 1-2. pp. 109-113.
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