Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type

Genomic Psychiatry Cohort Consortium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N=610), Bipolar disorder with psychosis (N=1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N=10065) using logistic regression. Among smokers (N=6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR=2.5; P<0.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR=1.3; P=0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR=1.2; P=0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume171
Issue number4
DOIs
StatePublished - Jun 1 2016

Fingerprint

Tobacco Use Disorder
Bipolar Disorder
Psychotic Disorders
Smoking
Nicotine
Smoke
Psychiatry
Logistic Models

Keywords

  • Cigarettes
  • Severe mental illness
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type. / Genomic Psychiatry Cohort Consortium.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 171, No. 4, 01.06.2016, p. 521-524.

Research output: Contribution to journalArticle

@article{f8f57363719c41d1a1bdb1ba35b461f5,
title = "Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type",
abstract = "Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N=610), Bipolar disorder with psychosis (N=1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N=10065) using logistic regression. Among smokers (N=6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR=2.5; P<0.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR=1.3; P=0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR=1.2; P=0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence.",
keywords = "Cigarettes, Severe mental illness, Smoking",
author = "{Genomic Psychiatry Cohort Consortium} and Elena Estrada and Hartz, {Sarah M.} and Jeffrey Tran and Hilty, {Donald M.} and Pamela Sklar and Smoller, {Jordan W.} and Pato, {Michele T.} and Pato, {Carlos N.} and Helena Medeiros and Sobell, {Janet L.} and Colony Abbott and Azevedo, {Maria Helena} and Antonio Macedo and Bromet, {Evelyn J.} and Buckley, {Peter F.} and Escamilla, {Michael A.} and Fanous, {Ayman H.} and Fochtmann, {Laura J.} and Lehrer, {Douglas S.} and Fabio Macciardi and Dolores Malaspina and Marder, {Stephen R.} and Morley, {Christopher P.} and Humberto Nicolini and Perkins, {Diana O.} and Rakofsky, {Jeffrey J.} and Rapaport, {Mark H.} and McCarroll, {Steven A.} and Becky Kincaid and Knowles, {James A.} and Marquis Vawter",
year = "2016",
month = "6",
day = "1",
doi = "10.1002/ajmg.b.32385",
language = "English (US)",
volume = "171",
pages = "521--524",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type

AU - Genomic Psychiatry Cohort Consortium

AU - Estrada, Elena

AU - Hartz, Sarah M.

AU - Tran, Jeffrey

AU - Hilty, Donald M.

AU - Sklar, Pamela

AU - Smoller, Jordan W.

AU - Pato, Michele T.

AU - Pato, Carlos N.

AU - Medeiros, Helena

AU - Sobell, Janet L.

AU - Abbott, Colony

AU - Azevedo, Maria Helena

AU - Macedo, Antonio

AU - Bromet, Evelyn J.

AU - Buckley, Peter F.

AU - Escamilla, Michael A.

AU - Fanous, Ayman H.

AU - Fochtmann, Laura J.

AU - Lehrer, Douglas S.

AU - Macciardi, Fabio

AU - Malaspina, Dolores

AU - Marder, Stephen R.

AU - Morley, Christopher P.

AU - Nicolini, Humberto

AU - Perkins, Diana O.

AU - Rakofsky, Jeffrey J.

AU - Rapaport, Mark H.

AU - McCarroll, Steven A.

AU - Kincaid, Becky

AU - Knowles, James A.

AU - Vawter, Marquis

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N=610), Bipolar disorder with psychosis (N=1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N=10065) using logistic regression. Among smokers (N=6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR=2.5; P<0.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR=1.3; P=0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR=1.2; P=0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence.

AB - Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N=610), Bipolar disorder with psychosis (N=1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N=10065) using logistic regression. Among smokers (N=6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR=2.5; P<0.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR=1.3; P=0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR=1.2; P=0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence.

KW - Cigarettes

KW - Severe mental illness

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84951964614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951964614&partnerID=8YFLogxK

U2 - 10.1002/ajmg.b.32385

DO - 10.1002/ajmg.b.32385

M3 - Article

C2 - 26467098

AN - SCOPUS:84951964614

VL - 171

SP - 521

EP - 524

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 4

ER -