Nitric oxide regulation of ADP-ribosylation of G proteins in hypertension

N. L. Kanagy, J. R. Charpie, R Clinton Webb

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Nitric oxide stimulates endogenous ADP-ribosylation of cytosolic and membrane-bound proteins. Endogenous ADP-ribosyltransferases modify several intracellular proteins including the heterotrimeric GTP-binding proteins (G proteins). ADP-ribosylation of G proteins in vascular smooth muscle leads to increased activation of adenylate cyclase and decreased activation of phospholipase C leading to vasodilation. We hypothesize that in hypertension, chronically depressed endothelium-derived nitric oxide levels lead to decreased ADP-ribosylation of G proteins. This reduced ADP-ribosylation leads to vasoconstriction since activation of the G proteins by agonists is unopposed. Thus, disinhibition of G proteins, mediated by nitric oxide deficit, is responsible for the observed increased sensitivity to vasoconstrictor agonists in hypertension. This novel role for nitric oxide in hypertension will provide a new area of research for antihypertensive therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalMedical Hypotheses
Volume44
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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GTP-Binding Proteins
Adenosine Diphosphate
Nitric Oxide
Hypertension
ADP Ribose Transferases
Therapeutic Human Experimentation
Heterotrimeric GTP-Binding Proteins
Type C Phospholipases
Vasoconstrictor Agents
Vasoconstriction
Vascular Smooth Muscle
Adenylyl Cyclases
Vasodilation
Antihypertensive Agents
Membrane Proteins
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Developmental Biology
  • Drug Discovery

Cite this

Nitric oxide regulation of ADP-ribosylation of G proteins in hypertension. / Kanagy, N. L.; Charpie, J. R.; Webb, R Clinton.

In: Medical Hypotheses, Vol. 44, No. 3, 01.01.1995, p. 159-164.

Research output: Contribution to journalArticle

Kanagy, N. L. ; Charpie, J. R. ; Webb, R Clinton. / Nitric oxide regulation of ADP-ribosylation of G proteins in hypertension. In: Medical Hypotheses. 1995 ; Vol. 44, No. 3. pp. 159-164.
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