Nodular regenerative hyperplasia of the liver with portal vein thrombosis and hyperplasia of the adrenal gland

Tohru Fukai, Hiromi Ishibashi, Toshiro Noda, Kazufumi Dohmen, Jiro Kudo, Seiho Nagafuchi, Katsuo Sueishi, Taku Yamasaki, Hiroto Sameshima

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Nodular regenerative hyperplasia (NRH) of the liver is an uncommon entity of unknown origin and pathogenesis. We report here a case of NRH of the liver which was associated with portal vein thrombosis and adrenal hyperplasia. A 48-year-old man who was admitted for further examination of portal hypertension and splenomegaly, died of acute myocardial infarction. Autopsy revealed an enlarged heart with occluded coronary arteries and fresh multiple necrosis in the myocardium. The spleen and the liver were enlarged. In the liver diffusely distributed nodules of regenerative hyperplasia were noted. Organized thrombi of the portal vein and adenomatous hyperplasia of the left adrenal gland were also noted. Antinuclear antibody was positive in the serum.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalGastroenterologia Japonica
Issue number1
Publication statusPublished - Feb 1 1992
Externally publishedYes



  • adrenal gland hyperplasia
  • antinuclear antibody
  • nodular regenerative hyperplasia
  • portal vein thrombosis

ASJC Scopus subject areas

  • Gastroenterology

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