Non-ionic diffusion of pentobarbital across human chorion laeve

J. J. Schruefer, D. R. Haburchak, K. D. Garlid, A. E. Seeds

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Diffusion of the weak organic acid, pentobarbital, across human chorion laeve in vitro shows an inverse correlation with pH, when corrected for extracellular space permeation by the concurrent measurement of membrane permeability to the lipid insoluble molecule, p-aminohippurate. The temperature dependence of pentobarbital diffusion at different pHs supports the concept that the additional net flux of solute at lower pH occurs by transcellular permeation by the non-ionized moiety, the observed increase corresponding roughly to the dissociation curve for pentobarbital.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalNeonatology
Volume27
Issue number3-4
DOIs
StatePublished - Jan 1 1975

Keywords

  • Human chorion laeve permeability
  • Non-ionic diffusion
  • Pentobarbital diffusivity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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  • Cite this

    Schruefer, J. J., Haburchak, D. R., Garlid, K. D., & Seeds, A. E. (1975). Non-ionic diffusion of pentobarbital across human chorion laeve. Neonatology, 27(3-4), 251-258. https://doi.org/10.1159/000240781