Non-surgical management of stress urinary incontinence

Ambulatory treatments for leakage associated with stress (ATLAS) trial

Holly E. Richter, Kathryn L. Burgio, Patricia S. Goode, Diane Borello-France, Catherine S. Bradley, Linda Brubaker, Victoria L. Handa, Paul M. Fine, Anthony G. Visco, Halina M. Zyczynski, John T. Wei, Anne M. Weber, Holly E. Richter, Kathryn L. Burgio, Patricia S. Goode, R. Edward Varner, Gregg Shore, Velria Willis, Paul M. Fine, Rodney A. Appell & 45 others Peter K. Thompson, Peter M. Lotze, Naomi Frierson, Karl Kreder, Denise Haury, Debra Brandt, Catherine S. Bradley, Ingrid Nygaard, Satish Rao, Geoffrey Cundiff, Victoria Handa, Mary Elizabeth Sauter, Jamie Wright, Linda Brubaker, Mary Pat FitzGerald, Kimberly Kenton, Elizabeth Mueller, Kathy Marchese, Judith Senka, Kathleen Jesse, Morton B. Brown, John T. Wei, Beverly Marchant, John O.L. DeLancey, Nancy K. Janz, Patricia A. Wren, James Imus, Yang Wang Casher, Dee Fenner, Anthony G. Visco, Anna Marie Connolly, John Lavelle, Mary J. Lavelle, Anita K. Murphy, Ellen C. Wells, William Whitehead, Julia Fielding, Halina Zyczynski, Diane Borello-France, Christiane Hakim, Arnold Wald, Judy A. Gruss, Wendy Leng, Pamela A. Moalli, Robert Park

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. Purpose: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. Methods: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). Limitations: The study design reduces most common biases, but some degree of selection bias may remain. Conclusion: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalClinical Trials
Volume4
Issue number1
DOIs
StatePublished - Dec 1 2007

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Stress Urinary Incontinence
Pelvic Floor
Pessaries
Therapeutics
Urinary Bladder
Outcome Assessment (Health Care)
Pelvic Organ Prolapse
Selection Bias
Urinary Incontinence
Random Allocation
Health Surveys
Patient Satisfaction
Randomized Controlled Trials
Prospective Studies
Exercise
Equipment and Supplies
Muscles

ASJC Scopus subject areas

  • Pharmacology

Cite this

Richter, H. E., Burgio, K. L., Goode, P. S., Borello-France, D., Bradley, C. S., Brubaker, L., ... Park, R. (2007). Non-surgical management of stress urinary incontinence: Ambulatory treatments for leakage associated with stress (ATLAS) trial. Clinical Trials, 4(1), 92-101. https://doi.org/10.1177/1740774506075237

Non-surgical management of stress urinary incontinence : Ambulatory treatments for leakage associated with stress (ATLAS) trial. / Richter, Holly E.; Burgio, Kathryn L.; Goode, Patricia S.; Borello-France, Diane; Bradley, Catherine S.; Brubaker, Linda; Handa, Victoria L.; Fine, Paul M.; Visco, Anthony G.; Zyczynski, Halina M.; Wei, John T.; Weber, Anne M.; Richter, Holly E.; Burgio, Kathryn L.; Goode, Patricia S.; Varner, R. Edward; Shore, Gregg; Willis, Velria; Fine, Paul M.; Appell, Rodney A.; Thompson, Peter K.; Lotze, Peter M.; Frierson, Naomi; Kreder, Karl; Haury, Denise; Brandt, Debra; Bradley, Catherine S.; Nygaard, Ingrid; Rao, Satish; Cundiff, Geoffrey; Handa, Victoria; Sauter, Mary Elizabeth; Wright, Jamie; Brubaker, Linda; FitzGerald, Mary Pat; Kenton, Kimberly; Mueller, Elizabeth; Marchese, Kathy; Senka, Judith; Jesse, Kathleen; Brown, Morton B.; Wei, John T.; Marchant, Beverly; DeLancey, John O.L.; Janz, Nancy K.; Wren, Patricia A.; Imus, James; Casher, Yang Wang; Fenner, Dee; Visco, Anthony G.; Connolly, Anna Marie; Lavelle, John; Lavelle, Mary J.; Murphy, Anita K.; Wells, Ellen C.; Whitehead, William; Fielding, Julia; Zyczynski, Halina; Borello-France, Diane; Hakim, Christiane; Wald, Arnold; Gruss, Judy A.; Leng, Wendy; Moalli, Pamela A.; Park, Robert.

In: Clinical Trials, Vol. 4, No. 1, 01.12.2007, p. 92-101.

Research output: Contribution to journalArticle

Richter, HE, Burgio, KL, Goode, PS, Borello-France, D, Bradley, CS, Brubaker, L, Handa, VL, Fine, PM, Visco, AG, Zyczynski, HM, Wei, JT, Weber, AM, Richter, HE, Burgio, KL, Goode, PS, Varner, RE, Shore, G, Willis, V, Fine, PM, Appell, RA, Thompson, PK, Lotze, PM, Frierson, N, Kreder, K, Haury, D, Brandt, D, Bradley, CS, Nygaard, I, Rao, S, Cundiff, G, Handa, V, Sauter, ME, Wright, J, Brubaker, L, FitzGerald, MP, Kenton, K, Mueller, E, Marchese, K, Senka, J, Jesse, K, Brown, MB, Wei, JT, Marchant, B, DeLancey, JOL, Janz, NK, Wren, PA, Imus, J, Casher, YW, Fenner, D, Visco, AG, Connolly, AM, Lavelle, J, Lavelle, MJ, Murphy, AK, Wells, EC, Whitehead, W, Fielding, J, Zyczynski, H, Borello-France, D, Hakim, C, Wald, A, Gruss, JA, Leng, W, Moalli, PA & Park, R 2007, 'Non-surgical management of stress urinary incontinence: Ambulatory treatments for leakage associated with stress (ATLAS) trial', Clinical Trials, vol. 4, no. 1, pp. 92-101. https://doi.org/10.1177/1740774506075237
Richter, Holly E. ; Burgio, Kathryn L. ; Goode, Patricia S. ; Borello-France, Diane ; Bradley, Catherine S. ; Brubaker, Linda ; Handa, Victoria L. ; Fine, Paul M. ; Visco, Anthony G. ; Zyczynski, Halina M. ; Wei, John T. ; Weber, Anne M. ; Richter, Holly E. ; Burgio, Kathryn L. ; Goode, Patricia S. ; Varner, R. Edward ; Shore, Gregg ; Willis, Velria ; Fine, Paul M. ; Appell, Rodney A. ; Thompson, Peter K. ; Lotze, Peter M. ; Frierson, Naomi ; Kreder, Karl ; Haury, Denise ; Brandt, Debra ; Bradley, Catherine S. ; Nygaard, Ingrid ; Rao, Satish ; Cundiff, Geoffrey ; Handa, Victoria ; Sauter, Mary Elizabeth ; Wright, Jamie ; Brubaker, Linda ; FitzGerald, Mary Pat ; Kenton, Kimberly ; Mueller, Elizabeth ; Marchese, Kathy ; Senka, Judith ; Jesse, Kathleen ; Brown, Morton B. ; Wei, John T. ; Marchant, Beverly ; DeLancey, John O.L. ; Janz, Nancy K. ; Wren, Patricia A. ; Imus, James ; Casher, Yang Wang ; Fenner, Dee ; Visco, Anthony G. ; Connolly, Anna Marie ; Lavelle, John ; Lavelle, Mary J. ; Murphy, Anita K. ; Wells, Ellen C. ; Whitehead, William ; Fielding, Julia ; Zyczynski, Halina ; Borello-France, Diane ; Hakim, Christiane ; Wald, Arnold ; Gruss, Judy A. ; Leng, Wendy ; Moalli, Pamela A. ; Park, Robert. / Non-surgical management of stress urinary incontinence : Ambulatory treatments for leakage associated with stress (ATLAS) trial. In: Clinical Trials. 2007 ; Vol. 4, No. 1. pp. 92-101.
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abstract = "Background: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. Purpose: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. Methods: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). Limitations: The study design reduces most common biases, but some degree of selection bias may remain. Conclusion: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.",
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TY - JOUR

T1 - Non-surgical management of stress urinary incontinence

T2 - Ambulatory treatments for leakage associated with stress (ATLAS) trial

AU - Richter, Holly E.

AU - Burgio, Kathryn L.

AU - Goode, Patricia S.

AU - Borello-France, Diane

AU - Bradley, Catherine S.

AU - Brubaker, Linda

AU - Handa, Victoria L.

AU - Fine, Paul M.

AU - Visco, Anthony G.

AU - Zyczynski, Halina M.

AU - Wei, John T.

AU - Weber, Anne M.

AU - Richter, Holly E.

AU - Burgio, Kathryn L.

AU - Goode, Patricia S.

AU - Varner, R. Edward

AU - Shore, Gregg

AU - Willis, Velria

AU - Fine, Paul M.

AU - Appell, Rodney A.

AU - Thompson, Peter K.

AU - Lotze, Peter M.

AU - Frierson, Naomi

AU - Kreder, Karl

AU - Haury, Denise

AU - Brandt, Debra

AU - Bradley, Catherine S.

AU - Nygaard, Ingrid

AU - Rao, Satish

AU - Cundiff, Geoffrey

AU - Handa, Victoria

AU - Sauter, Mary Elizabeth

AU - Wright, Jamie

AU - Brubaker, Linda

AU - FitzGerald, Mary Pat

AU - Kenton, Kimberly

AU - Mueller, Elizabeth

AU - Marchese, Kathy

AU - Senka, Judith

AU - Jesse, Kathleen

AU - Brown, Morton B.

AU - Wei, John T.

AU - Marchant, Beverly

AU - DeLancey, John O.L.

AU - Janz, Nancy K.

AU - Wren, Patricia A.

AU - Imus, James

AU - Casher, Yang Wang

AU - Fenner, Dee

AU - Visco, Anthony G.

AU - Connolly, Anna Marie

AU - Lavelle, John

AU - Lavelle, Mary J.

AU - Murphy, Anita K.

AU - Wells, Ellen C.

AU - Whitehead, William

AU - Fielding, Julia

AU - Zyczynski, Halina

AU - Borello-France, Diane

AU - Hakim, Christiane

AU - Wald, Arnold

AU - Gruss, Judy A.

AU - Leng, Wendy

AU - Moalli, Pamela A.

AU - Park, Robert

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. Purpose: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. Methods: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). Limitations: The study design reduces most common biases, but some degree of selection bias may remain. Conclusion: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.

AB - Background: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. Purpose: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. Methods: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). Limitations: The study design reduces most common biases, but some degree of selection bias may remain. Conclusion: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.

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