Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

Feng Ming Kong, Shulian Wang

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalSeminars in Radiation Oncology
Volume25
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Radiation
Lung
Radiotherapy
Radiometry
Pulmonary Fibrosis
Spirometry
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity. / Kong, Feng Ming; Wang, Shulian.

In: Seminars in Radiation Oncology, Vol. 25, No. 2, 01.04.2015, p. 100-109.

Research output: Contribution to journalReview article

Kong, Feng Ming ; Wang, Shulian. / Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity. In: Seminars in Radiation Oncology. 2015 ; Vol. 25, No. 2. pp. 100-109.
@article{ab046352ea22404cb542dc69923419ab,
title = "Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity",
abstract = "The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.",
author = "Kong, {Feng Ming} and Shulian Wang",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.semradonc.2014.12.003",
language = "English (US)",
volume = "25",
pages = "100--109",
journal = "Seminars in Radiation Oncology",
issn = "1053-4296",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

AU - Kong, Feng Ming

AU - Wang, Shulian

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.

AB - The decision to administer a radical course of radiotherapy (RT) is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient-related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and a relative contraindication for patients undergoing radical RT, but recent evidence suggests that patients with poor spirometry results may tolerate conventional or high-dose RT as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Furthermore, there is emerging evidence of molecular markers of increased risk of toxicity. This review discusses patient-related risk factors other than dosimetry for radiation lung toxicity.

UR - http://www.scopus.com/inward/record.url?scp=84961289904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961289904&partnerID=8YFLogxK

U2 - 10.1016/j.semradonc.2014.12.003

DO - 10.1016/j.semradonc.2014.12.003

M3 - Review article

VL - 25

SP - 100

EP - 109

JO - Seminars in Radiation Oncology

JF - Seminars in Radiation Oncology

SN - 1053-4296

IS - 2

ER -