Nosocomial Candida glabrata colonization

An epidemiologic study

Jose Antonio Vazquez, Louise M. Dembry, Veronica Sanchez, Mary A. Vazquez, Jack D. Sobel, Carl Dmuchowski, Marcus J. Zervos

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Candida glabrata has emerged as an important nosocomial pathogen, yet little is known about its epidemiology. We prospectively followed 98 patients admitted to a medical intensive care unit and the bone marrow transplant unit of a university hospital. Samples from environmental surfaces and the hands of hospital personnel were also cultured. Patients with newly acquired C. glabrata strains were compared to controls who were culture negative for C. glabrata. C. glabrata was recovered from multiple sites from 24 patients and three environmental surfaces. Sixteen patients (17%) acquired C. glabrata after admission to the study units. Significant risk factors for the nosocomial acquisition of C. glabrata were prolonged duration of hospitalization in the unit and prior antimicrobial use. Strain delineation by restriction enzyme analysis revealed 28 different strains of C. glabrata; three strain types were common to nine patients. The environmental isolates were of the same strain type and common to five patients (four patients with newly acquired strains). These results suggest the possibility of exogenous nosocomial acquisition of C. glabrata, including the possible acquisition from the hospital environment. Transmission may be by indirect contact since identical strains of C. glabrata were recovered from patients who were geographically and temporally associated.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Clinical Microbiology
Volume36
Issue number2
StatePublished - Feb 1 1998
Externally publishedYes

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Candida glabrata
Epidemiologic Studies
Hospital Personnel
Restriction Mapping
Intensive Care Units
Epidemiology
Hospitalization
Hand
Bone Marrow
Transplants

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Vazquez, J. A., Dembry, L. M., Sanchez, V., Vazquez, M. A., Sobel, J. D., Dmuchowski, C., & Zervos, M. J. (1998). Nosocomial Candida glabrata colonization: An epidemiologic study. Journal of Clinical Microbiology, 36(2), 421-426.

Nosocomial Candida glabrata colonization : An epidemiologic study. / Vazquez, Jose Antonio; Dembry, Louise M.; Sanchez, Veronica; Vazquez, Mary A.; Sobel, Jack D.; Dmuchowski, Carl; Zervos, Marcus J.

In: Journal of Clinical Microbiology, Vol. 36, No. 2, 01.02.1998, p. 421-426.

Research output: Contribution to journalArticle

Vazquez, JA, Dembry, LM, Sanchez, V, Vazquez, MA, Sobel, JD, Dmuchowski, C & Zervos, MJ 1998, 'Nosocomial Candida glabrata colonization: An epidemiologic study', Journal of Clinical Microbiology, vol. 36, no. 2, pp. 421-426.
Vazquez JA, Dembry LM, Sanchez V, Vazquez MA, Sobel JD, Dmuchowski C et al. Nosocomial Candida glabrata colonization: An epidemiologic study. Journal of Clinical Microbiology. 1998 Feb 1;36(2):421-426.
Vazquez, Jose Antonio ; Dembry, Louise M. ; Sanchez, Veronica ; Vazquez, Mary A. ; Sobel, Jack D. ; Dmuchowski, Carl ; Zervos, Marcus J. / Nosocomial Candida glabrata colonization : An epidemiologic study. In: Journal of Clinical Microbiology. 1998 ; Vol. 36, No. 2. pp. 421-426.
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