Novel treatments for obesity and osteoporosis: Targeting apoptotic pathways in adipocytes

C. Nelson-Dooley, M. A. Della-Fera, Mark W Hamrick, C. A. Baile

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Obesity and osteoporosis have grave consequences for human health, quality of life, and even the efficiency of the labor force and economy. However, these pathologies share a common cell progenitor, revealing a surprising target for drug research and development. Recent findings show that high adipocyte count in bone marrow is directly related to bone loss, as fat cells replace osteoblasts (or bone-forming cells). The objective of this review is to examine the importance of adipocyte apoptosis in the treatment of obesity and/or osteoporosis, with special emphasis on natural products as promising leads for drug development. We have induced in vivo adipocyte apoptosis, using leptin, ciliary neurotrophic factor (CNTF), beta adrenergic agonists and conjugated linoleic acid (CLA) in rodents. The results of leptin treatments on rats are suppressed food intake, reduced body weight, reduced body fat, adipocyte apoptosis, and elevated energy expenditure. Further, leptin treatment of leptin-deficient (ob/ob) mice increases endosteal bone formation and bone mineral density. Adipocyte apoptosis has also been induced in vitro using tumor necrosis factor-alpha (TNF-α), (-)-epigallocatechin gallate (EGCG) from Camellia sinensis and ajoene, from Allium sativum. Natural products have potential for inducing apoptosis of adipose tissue, inhibiting bone marrow adipogenesis and increasing the expression of osteogenic factors in bone, thereby yielding effective treatments for obesity and osteoporosis.

Original languageEnglish (US)
Pages (from-to)2215-2225
Number of pages11
JournalCurrent Medicinal Chemistry
Volume12
Issue number19
DOIs
StatePublished - Aug 31 2005

Fingerprint

Adipocytes
Osteoporosis
Bone
Obesity
Leptin
Apoptosis
Bone and Bones
Biological Products
Adipose Tissue
Bone Marrow
Camellia sinensis
Ciliary Neurotrophic Factor
Conjugated Linoleic Acids
Fats
Adipogenesis
Adrenergic beta-Agonists
Garlic
Osteoblasts
Osteogenesis
Pharmaceutical Preparations

Keywords

  • Adipocyte apoptosis
  • Ajoene
  • CLA
  • EGCG
  • Flavonoids
  • Mesenchymal differentiation
  • Osteogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Novel treatments for obesity and osteoporosis : Targeting apoptotic pathways in adipocytes. / Nelson-Dooley, C.; Della-Fera, M. A.; Hamrick, Mark W; Baile, C. A.

In: Current Medicinal Chemistry, Vol. 12, No. 19, 31.08.2005, p. 2215-2225.

Research output: Contribution to journalReview article

Nelson-Dooley, C. ; Della-Fera, M. A. ; Hamrick, Mark W ; Baile, C. A. / Novel treatments for obesity and osteoporosis : Targeting apoptotic pathways in adipocytes. In: Current Medicinal Chemistry. 2005 ; Vol. 12, No. 19. pp. 2215-2225.
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