NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion

Maria Eugenia Sabbatini, Marcelo S. Vatta, Cristina Vescina, Soledad Gonzales, Belisario Fernandez, Liliana G. Bianciotti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family. Previous studies reported the presence of natriuretic peptide receptors and mRNA CNP in the liver. In the present work, we sought to establish the role of CNP in the regulation of bile secretion in the rat and the possible pathways involved. CNP diminished basal as well as bile salt-evoked bile flow and bile acid output in a dose-dependent manner. It also reduced the excretion of sodium, chloride, and potassium but did not modify bile pH or the excretion of phospholipids, total proteins, and glutathione. Neither parasympathetic nor sympathetic blockade abolished CNP inhibitory response on bile secretion. The selective NPR-C agonist, C-ANP-(4-23) amide, diminished bile flow and the co-administration of both peptides did not further decrease it. CNP did not alter mean arterial pressure or portal venous pressure at any given doses. CNP decreased bile acid-dependent flow without affecting bile acid-independent flow. The inhibitory effect of CNP did not involve the participation of the autonomic nervous system or hemodynamic changes. The participation of NPR-C receptors in CNP response is strongly supported by present findings. The present study shows that CNP modulates bile secretion in the rat, suggesting that CNP may be part of the large family of peptides involved in the regulation of gastrointestinal physiology.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalRegulatory Peptides
Volume116
Issue number1-3
DOIs
StatePublished - Nov 15 2003
Externally publishedYes

Fingerprint

C-Type Natriuretic Peptide
Bile
Bile Acids and Salts
Natriuretic Peptides
Rats
Portal Pressure
Peptides
Peptide Receptors
Autonomic Nervous System
Physiology
Hemodynamics
Neurology
Sodium Chloride
Amides
Liver
Glutathione
Phospholipids
Potassium
Arterial Pressure

Keywords

  • Autonomic nervous system
  • Bile acids
  • Bile flow
  • C-ANP-(4-23)
  • CNP
  • Glutathione

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion. / Sabbatini, Maria Eugenia; Vatta, Marcelo S.; Vescina, Cristina; Gonzales, Soledad; Fernandez, Belisario; Bianciotti, Liliana G.

In: Regulatory Peptides, Vol. 116, No. 1-3, 15.11.2003, p. 13-20.

Research output: Contribution to journalArticle

Sabbatini, ME, Vatta, MS, Vescina, C, Gonzales, S, Fernandez, B & Bianciotti, LG 2003, 'NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion', Regulatory Peptides, vol. 116, no. 1-3, pp. 13-20. https://doi.org/10.1016/S0167-0115(03)00168-X
Sabbatini, Maria Eugenia ; Vatta, Marcelo S. ; Vescina, Cristina ; Gonzales, Soledad ; Fernandez, Belisario ; Bianciotti, Liliana G. / NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion. In: Regulatory Peptides. 2003 ; Vol. 116, No. 1-3. pp. 13-20.
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