Numerical simulation of embryo transfer: How the viscosity of transferred medium affects the transport of embryos

Dali Ding, Weiping Shi, Yang Shi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Embryo transfer (ET) is a key step of assisted reproductive procedures, where the transferred medium containing the embryos is injected into the uterine cavity through a transcervical catheter and blended with intrauterine fluid in the uterine cavity. This procedure determines the delivery sites of embryos in the uterine cavity and has crucial impact on the implantation. Due to practical restrictions and ethical issues, it is often difficult to perform an in vivo study in humans to examine factors that affect the motions and delivery of embryos during ET. Alternatively, mathematical modeling is a powerful tool to that end. Results: A computational model is developed to simulate the intrauterine mixing flow and track the embryo motions. Two important factors affecting the intrauterine flow are studied via this model: the viscosity of the transferred medium and the injection speed. Numerical results show that the dispersion pattern and the final delivery sites of the embryos are significantly influenced by the viscosity of the transferred medium. Specially, increasing the transferred medium viscosity close to that of the uterine fluid can enhance the probability that the embryos are delivered close to the fundus and keep them from being dragged backward to the cervix during catheter withdrawal. In addition, a slow injection speed can lower the driving force on the embryo during ET, which can prevent the embryo from being injured. Conclusions: Based on our study, the practice of using a transferred medium with similar viscosity to that of the uterine fluid and a slow injection speed is recommended for real embryo transfer procedures in clinic.

Original languageEnglish (US)
Article number20
JournalTheoretical Biology and Medical Modelling
Volume15
Issue number1
DOIs
StatePublished - Oct 5 2018

Fingerprint

Embryo Transfer
Embryo
Viscosity
Embryonic Structures
Numerical Simulation
Catheters
Computer simulation
Fluids
Injection
Cavity
Fluid
Injections
Implantation
Motion
Driving Force
Ethics
Cervix Uteri
Mathematical Modeling
Computational Model
Restriction

Keywords

  • Dispersion pattern
  • Embryo transfer
  • In vitro fertilization
  • Mixing flow
  • Multiphase flow
  • Numerical simulation
  • Viscosity of transferred medium

ASJC Scopus subject areas

  • Modeling and Simulation
  • Health Informatics

Cite this

Numerical simulation of embryo transfer : How the viscosity of transferred medium affects the transport of embryos. / Ding, Dali; Shi, Weiping; Shi, Yang.

In: Theoretical Biology and Medical Modelling, Vol. 15, No. 1, 20, 05.10.2018.

Research output: Contribution to journalArticle

@article{78ad3a8b900e499382670a5396f3420d,
title = "Numerical simulation of embryo transfer: How the viscosity of transferred medium affects the transport of embryos",
abstract = "Background: Embryo transfer (ET) is a key step of assisted reproductive procedures, where the transferred medium containing the embryos is injected into the uterine cavity through a transcervical catheter and blended with intrauterine fluid in the uterine cavity. This procedure determines the delivery sites of embryos in the uterine cavity and has crucial impact on the implantation. Due to practical restrictions and ethical issues, it is often difficult to perform an in vivo study in humans to examine factors that affect the motions and delivery of embryos during ET. Alternatively, mathematical modeling is a powerful tool to that end. Results: A computational model is developed to simulate the intrauterine mixing flow and track the embryo motions. Two important factors affecting the intrauterine flow are studied via this model: the viscosity of the transferred medium and the injection speed. Numerical results show that the dispersion pattern and the final delivery sites of the embryos are significantly influenced by the viscosity of the transferred medium. Specially, increasing the transferred medium viscosity close to that of the uterine fluid can enhance the probability that the embryos are delivered close to the fundus and keep them from being dragged backward to the cervix during catheter withdrawal. In addition, a slow injection speed can lower the driving force on the embryo during ET, which can prevent the embryo from being injured. Conclusions: Based on our study, the practice of using a transferred medium with similar viscosity to that of the uterine fluid and a slow injection speed is recommended for real embryo transfer procedures in clinic.",
keywords = "Dispersion pattern, Embryo transfer, In vitro fertilization, Mixing flow, Multiphase flow, Numerical simulation, Viscosity of transferred medium",
author = "Dali Ding and Weiping Shi and Yang Shi",
year = "2018",
month = "10",
day = "5",
doi = "10.1186/s12976-018-0092-y",
language = "English (US)",
volume = "15",
journal = "Theoretical Biology and Medical Modelling",
issn = "1742-4682",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Numerical simulation of embryo transfer

T2 - How the viscosity of transferred medium affects the transport of embryos

AU - Ding, Dali

AU - Shi, Weiping

AU - Shi, Yang

PY - 2018/10/5

Y1 - 2018/10/5

N2 - Background: Embryo transfer (ET) is a key step of assisted reproductive procedures, where the transferred medium containing the embryos is injected into the uterine cavity through a transcervical catheter and blended with intrauterine fluid in the uterine cavity. This procedure determines the delivery sites of embryos in the uterine cavity and has crucial impact on the implantation. Due to practical restrictions and ethical issues, it is often difficult to perform an in vivo study in humans to examine factors that affect the motions and delivery of embryos during ET. Alternatively, mathematical modeling is a powerful tool to that end. Results: A computational model is developed to simulate the intrauterine mixing flow and track the embryo motions. Two important factors affecting the intrauterine flow are studied via this model: the viscosity of the transferred medium and the injection speed. Numerical results show that the dispersion pattern and the final delivery sites of the embryos are significantly influenced by the viscosity of the transferred medium. Specially, increasing the transferred medium viscosity close to that of the uterine fluid can enhance the probability that the embryos are delivered close to the fundus and keep them from being dragged backward to the cervix during catheter withdrawal. In addition, a slow injection speed can lower the driving force on the embryo during ET, which can prevent the embryo from being injured. Conclusions: Based on our study, the practice of using a transferred medium with similar viscosity to that of the uterine fluid and a slow injection speed is recommended for real embryo transfer procedures in clinic.

AB - Background: Embryo transfer (ET) is a key step of assisted reproductive procedures, where the transferred medium containing the embryos is injected into the uterine cavity through a transcervical catheter and blended with intrauterine fluid in the uterine cavity. This procedure determines the delivery sites of embryos in the uterine cavity and has crucial impact on the implantation. Due to practical restrictions and ethical issues, it is often difficult to perform an in vivo study in humans to examine factors that affect the motions and delivery of embryos during ET. Alternatively, mathematical modeling is a powerful tool to that end. Results: A computational model is developed to simulate the intrauterine mixing flow and track the embryo motions. Two important factors affecting the intrauterine flow are studied via this model: the viscosity of the transferred medium and the injection speed. Numerical results show that the dispersion pattern and the final delivery sites of the embryos are significantly influenced by the viscosity of the transferred medium. Specially, increasing the transferred medium viscosity close to that of the uterine fluid can enhance the probability that the embryos are delivered close to the fundus and keep them from being dragged backward to the cervix during catheter withdrawal. In addition, a slow injection speed can lower the driving force on the embryo during ET, which can prevent the embryo from being injured. Conclusions: Based on our study, the practice of using a transferred medium with similar viscosity to that of the uterine fluid and a slow injection speed is recommended for real embryo transfer procedures in clinic.

KW - Dispersion pattern

KW - Embryo transfer

KW - In vitro fertilization

KW - Mixing flow

KW - Multiphase flow

KW - Numerical simulation

KW - Viscosity of transferred medium

UR - http://www.scopus.com/inward/record.url?scp=85054436330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054436330&partnerID=8YFLogxK

U2 - 10.1186/s12976-018-0092-y

DO - 10.1186/s12976-018-0092-y

M3 - Article

C2 - 30290814

AN - SCOPUS:85054436330

VL - 15

JO - Theoretical Biology and Medical Modelling

JF - Theoretical Biology and Medical Modelling

SN - 1742-4682

IS - 1

M1 - 20

ER -