Oligometastatic status as predictor of survival in metastatic human papillomavirus-positive oropharyngeal carcinoma

William Greer Albergotti, Shira Abberbock, Fasil Mathews, Robert L. Ferris, Jonas T. Johnson, Umamaheswar Duvvuri, Seungwon Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Oligometastasis is a good prognostic indicator when compared to widely metastatic disease in malignancies of other organ systems. We hypothesized that oligometastasis in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) would be associated with better overall survival. Methods: This is a retrospective review of all HPV-positive oropharyngeal SCC treated at one center with at least 1-year of follow-up. Patients were stratified into 2 cohorts: oligometastasis (1-2 metastases, confined to 1 organ system) or polymetastasis (>2 metastases or multiple organ involvement) with cohorts compared for time to distant metastasis and overall survival after metastasis. Results: Thirty-eight of 506 patients (7.5%) developed metachronous distant metastasis; 12 developed oligometastasis and 26 developed polymetastasis. Median overall survival after oligometastasis was significantly longer than polymetastasis at 45 months (95% confidence interval [CI] 19 months - not reached) and 10 months (95% CI 5-24 months; P =.00028). Conclusion: Oligometastasis in metastatic HPV-positive oropharyngeal SCC portends a better prognosis than polymetastasis.

Original languageEnglish (US)
Pages (from-to)1685-1690
Number of pages6
JournalHead and Neck
Volume40
Issue number8
DOIs
StatePublished - Aug 1 2018

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Neoplasm Metastasis
Carcinoma
Survival
Squamous Cell Carcinoma
Confidence Intervals
Neoplasms

Keywords

  • human papillomavirus
  • metastatic
  • oligometastasis
  • oropharyngeal
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Oligometastatic status as predictor of survival in metastatic human papillomavirus-positive oropharyngeal carcinoma. / Albergotti, William Greer; Abberbock, Shira; Mathews, Fasil; Ferris, Robert L.; Johnson, Jonas T.; Duvvuri, Umamaheswar; Kim, Seungwon.

In: Head and Neck, Vol. 40, No. 8, 01.08.2018, p. 1685-1690.

Research output: Contribution to journalArticle

Albergotti, William Greer ; Abberbock, Shira ; Mathews, Fasil ; Ferris, Robert L. ; Johnson, Jonas T. ; Duvvuri, Umamaheswar ; Kim, Seungwon. / Oligometastatic status as predictor of survival in metastatic human papillomavirus-positive oropharyngeal carcinoma. In: Head and Neck. 2018 ; Vol. 40, No. 8. pp. 1685-1690.
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AU - Johnson, Jonas T.

AU - Duvvuri, Umamaheswar

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