"On water" synthesis of spiro-indoles via Schiff bases

Siva Shankar Panda, Subhash C. Jain

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic amines in water at room temperature to obtain corresponding Schiff bases in high purity and yield. These were then converted into corresponding spiro compounds using mercaptoacetic acid under microwave irradiation in neat conditions as well as in water on refluxing. Hence, a green synthetic protocol is developed to synthesize new molecules with improved profile under ecofriendly conditions, in which no wastes or side-products are formed.

Original languageEnglish (US)
Pages (from-to)1187-1194
Number of pages8
JournalMonatshefte fur Chemie
Volume143
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Cycloadditions
  • Green chemistry
  • Microwave
  • Schiff bases
  • Spiro compounds
  • Water

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of '"On water" synthesis of spiro-indoles via Schiff bases'. Together they form a unique fingerprint.

  • Cite this