"On water" synthesis of spiro-indoles via Schiff bases

Siva Shankar Panda, Subhash C. Jain

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic amines in water at room temperature to obtain corresponding Schiff bases in high purity and yield. These were then converted into corresponding spiro compounds using mercaptoacetic acid under microwave irradiation in neat conditions as well as in water on refluxing. Hence, a green synthetic protocol is developed to synthesize new molecules with improved profile under ecofriendly conditions, in which no wastes or side-products are formed.

Original languageEnglish (US)
Pages (from-to)1187-1194
Number of pages8
JournalMonatshefte fur Chemie
Volume143
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Indoles
Schiff Bases
Spiro Compounds
Microwave irradiation
Water
Amines
Molecules
Temperature

Keywords

  • Cycloadditions
  • Green chemistry
  • Microwave
  • Schiff bases
  • Spiro compounds
  • Water

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

"On water" synthesis of spiro-indoles via Schiff bases. / Panda, Siva Shankar; Jain, Subhash C.

In: Monatshefte fur Chemie, Vol. 143, No. 8, 01.08.2012, p. 1187-1194.

Research output: Contribution to journalArticle

Panda, Siva Shankar ; Jain, Subhash C. / "On water" synthesis of spiro-indoles via Schiff bases. In: Monatshefte fur Chemie. 2012 ; Vol. 143, No. 8. pp. 1187-1194.
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