Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Mucocutaneous candidiasis is frequently one of the first signs of human immunodeficiency virus (HIV) infection. Over 90% of patients with AIDS will develop oropharyngeal candidiasis (OPC) at some time during their illness. Although numerous antifungal agents are available, azoles, both topical (clotrimazole) and systemic (fluconazole, itraconazole, voriconazole, posaconazole) have replaced older topical antifungals (gentian violet and nystatin) in the management of oropharyngeal candidiasis in these patients. The systemic azoles, are generally safe and effective agents in HIV-infected patients with oropharyngeal candidiasis. A constant concern in these patients is relapse, which is dependent on the degree of immuno suppression commonly seen after topical therapy, rather than with systemic azole therapy. Candida esophagitis (CE) is also an important concern since it occurs in more than 10% of patients with AIDS and can lead to a decrease in oral intake and associated weight loss. Fluconazole has become the most widely used antifungal in the management of mucosal candidiasis. However, itraconazole and posaconazole have similar clinical response rates as fluconazole and are also effective alternative agents. In patients with fluconazole-refractory mucosal candidiasis, treatment options now include itraconazole solution, voriconazole, posaconazole, and the newer echinocandins (caspofungin, micafungin, and anidulafungin).

Original languageEnglish (US)
Pages (from-to)89-101
Number of pages13
JournalHIV/AIDS - Research and Palliative Care
Volume2
Publication statusPublished - Jul 19 2010
Externally publishedYes

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Keywords

  • AIDS
  • Antifungal agents
  • Esophageal candidiasis
  • HAART
  • HIV
  • Oropharyngeal candidiasis

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Dermatology
  • Infectious Diseases
  • Virology

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