Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins

Leo Tjäderhane, Fabio D. Nascimento, Lorenzo Breschi, Annalisa Mazzoni, Ivarne L.S. Tersariol, Saulo Geraldeli, Arzu Tezvergil-Mutluay, Marcela R. Carrilho, Ricardo M. Carvalho, Franklin R. Tay, David H. Pashley

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Objectives: Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. Methods: Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface. Results: The identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength. Significance: Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future.

Original languageEnglish (US)
Pages (from-to)116-135
Number of pages20
JournalDental Materials
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Cathepsins
Dentin
Matrix Metalloproteinases
Collagen
Cysteine
Adhesives
Durability
Degradation
Enzymes
Bond strength (materials)
Pathology
Hydrolysis
Resins
Tissue
Metalloproteases
Tooth

Keywords

  • Adhesive
  • Chlorhexidine
  • Collagen
  • Composite resin
  • Cysteine cathepsin
  • Degradation
  • Dentin
  • Durability
  • Matrix metalloproteinase
  • Tooth

ASJC Scopus subject areas

  • Materials Science(all)
  • Dentistry(all)
  • Mechanics of Materials

Cite this

Tjäderhane, L., Nascimento, F. D., Breschi, L., Mazzoni, A., Tersariol, I. L. S., Geraldeli, S., ... Pashley, D. H. (2013). Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. Dental Materials, 29(1), 116-135. https://doi.org/10.1016/j.dental.2012.08.004

Optimizing dentin bond durability : Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. / Tjäderhane, Leo; Nascimento, Fabio D.; Breschi, Lorenzo; Mazzoni, Annalisa; Tersariol, Ivarne L.S.; Geraldeli, Saulo; Tezvergil-Mutluay, Arzu; Carrilho, Marcela R.; Carvalho, Ricardo M.; Tay, Franklin R.; Pashley, David H.

In: Dental Materials, Vol. 29, No. 1, 01.01.2013, p. 116-135.

Research output: Contribution to journalArticle

Tjäderhane, L, Nascimento, FD, Breschi, L, Mazzoni, A, Tersariol, ILS, Geraldeli, S, Tezvergil-Mutluay, A, Carrilho, MR, Carvalho, RM, Tay, FR & Pashley, DH 2013, 'Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins', Dental Materials, vol. 29, no. 1, pp. 116-135. https://doi.org/10.1016/j.dental.2012.08.004
Tjäderhane, Leo ; Nascimento, Fabio D. ; Breschi, Lorenzo ; Mazzoni, Annalisa ; Tersariol, Ivarne L.S. ; Geraldeli, Saulo ; Tezvergil-Mutluay, Arzu ; Carrilho, Marcela R. ; Carvalho, Ricardo M. ; Tay, Franklin R. ; Pashley, David H. / Optimizing dentin bond durability : Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. In: Dental Materials. 2013 ; Vol. 29, No. 1. pp. 116-135.
@article{b4c8ecf431cd476f96c0cfdcac9f94a3,
title = "Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins",
abstract = "Objectives: Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. Methods: Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface. Results: The identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength. Significance: Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future.",
keywords = "Adhesive, Chlorhexidine, Collagen, Composite resin, Cysteine cathepsin, Degradation, Dentin, Durability, Matrix metalloproteinase, Tooth",
author = "Leo Tj{\"a}derhane and Nascimento, {Fabio D.} and Lorenzo Breschi and Annalisa Mazzoni and Tersariol, {Ivarne L.S.} and Saulo Geraldeli and Arzu Tezvergil-Mutluay and Carrilho, {Marcela R.} and Carvalho, {Ricardo M.} and Tay, {Franklin R.} and Pashley, {David H.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.dental.2012.08.004",
language = "English (US)",
volume = "29",
pages = "116--135",
journal = "Dental Materials",
issn = "0109-5641",
publisher = "Elsevier Science",
number = "1",

}

TY - JOUR

T1 - Optimizing dentin bond durability

T2 - Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins

AU - Tjäderhane, Leo

AU - Nascimento, Fabio D.

AU - Breschi, Lorenzo

AU - Mazzoni, Annalisa

AU - Tersariol, Ivarne L.S.

AU - Geraldeli, Saulo

AU - Tezvergil-Mutluay, Arzu

AU - Carrilho, Marcela R.

AU - Carvalho, Ricardo M.

AU - Tay, Franklin R.

AU - Pashley, David H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives: Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. Methods: Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface. Results: The identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength. Significance: Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future.

AB - Objectives: Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. Methods: Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface. Results: The identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength. Significance: Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future.

KW - Adhesive

KW - Chlorhexidine

KW - Collagen

KW - Composite resin

KW - Cysteine cathepsin

KW - Degradation

KW - Dentin

KW - Durability

KW - Matrix metalloproteinase

KW - Tooth

UR - http://www.scopus.com/inward/record.url?scp=84871020240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871020240&partnerID=8YFLogxK

U2 - 10.1016/j.dental.2012.08.004

DO - 10.1016/j.dental.2012.08.004

M3 - Article

C2 - 22901826

AN - SCOPUS:84871020240

VL - 29

SP - 116

EP - 135

JO - Dental Materials

JF - Dental Materials

SN - 0109-5641

IS - 1

ER -