Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse

E. H. Weiss, L. Golden, K. Fahrner, A. L. Mellor, J. J. Devlin, H. Bullman, H. Tiddens, H. Bud, R. A. Flavell

Research output: Contribution to journalArticle

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Abstract

The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalNature
Volume310
Issue number5979
DOIs
StatePublished - Dec 1 1984

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MHC Class I Genes
Major Histocompatibility Complex
Inbred C57BL Mouse
Multigene Family
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Weiss, E. H., Golden, L., Fahrner, K., Mellor, A. L., Devlin, J. J., Bullman, H., ... Flavell, R. A. (1984). Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature, 310(5979), 650-655. https://doi.org/10.1038/310650a0

Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse. / Weiss, E. H.; Golden, L.; Fahrner, K.; Mellor, A. L.; Devlin, J. J.; Bullman, H.; Tiddens, H.; Bud, H.; Flavell, R. A.

In: Nature, Vol. 310, No. 5979, 01.12.1984, p. 650-655.

Research output: Contribution to journalArticle

Weiss, EH, Golden, L, Fahrner, K, Mellor, AL, Devlin, JJ, Bullman, H, Tiddens, H, Bud, H & Flavell, RA 1984, 'Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse', Nature, vol. 310, no. 5979, pp. 650-655. https://doi.org/10.1038/310650a0
Weiss EH, Golden L, Fahrner K, Mellor AL, Devlin JJ, Bullman H et al. Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature. 1984 Dec 1;310(5979):650-655. https://doi.org/10.1038/310650a0
Weiss, E. H. ; Golden, L. ; Fahrner, K. ; Mellor, A. L. ; Devlin, J. J. ; Bullman, H. ; Tiddens, H. ; Bud, H. ; Flavell, R. A. / Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse. In: Nature. 1984 ; Vol. 310, No. 5979. pp. 650-655.
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