Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse

E. H. Weiss, L. Golden, K. Fahrner, A. L. Mellor, J. J. Devlin, H. Bullman, H. Tiddens, H. Bud, R. A. Flavell

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Abstract

The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalNature
Volume310
Issue number5979
DOIs
StatePublished - 1984

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    Weiss, E. H., Golden, L., Fahrner, K., Mellor, A. L., Devlin, J. J., Bullman, H., Tiddens, H., Bud, H., & Flavell, R. A. (1984). Organization and evolution of the class i gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature, 310(5979), 650-655. https://doi.org/10.1038/310650a0