Osteogenesis in composite grafts of allogenic demineralized bone powder and porous hydroxylapatite

Mohamed El Deeb, Mahmoud Hosny, Mohamed M.H. Sharawy

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This study evaluated the osteoinductive capabilities of porous hydroxylapatite (PH) and the tissue response following intramuscular implantation of PH alone or in combination with demineralized bone powder (DBP). Six rhesus monkeys each received the implants in three separate soft tissue pockets created in the thoracic region. The implants consisted of 2 cc of either PH alone or DBP alone, or a 1:1 combination of DBP and PH. Two animals were killed at 2 weeks, two at 4 weeks, and two at 12 weeks postimplantation. Histologically, bone formation was seen in the DBP mixed with PH and in the DBP group as early as 4 weeks postimplantation; bone was also occasionally observed within the pores of the PH particles. The PH alone showed no evidence of formation of bone and the material was surrounded by a thick layer of fibrous tissue. It was concluded that PH is not osteoinductive, but can act as a scaffold for growth of bone, and that when mixed with an osteoinductive material, it allows for formation of bone within the implant.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalJournal of Oral and Maxillofacial Surgery
Volume47
Issue number1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Durapatite
Osteogenesis
Powders
Transplants
Bone and Bones
Bone Development
Macaca mulatta
Thorax

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Osteogenesis in composite grafts of allogenic demineralized bone powder and porous hydroxylapatite. / Deeb, Mohamed El; Hosny, Mahmoud; Sharawy, Mohamed M.H.

In: Journal of Oral and Maxillofacial Surgery, Vol. 47, No. 1, 01.01.1989, p. 50-56.

Research output: Contribution to journalArticle

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