Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission.

Hagop M. Kantarjian, Deborah Thomas, Farhad Ravandi, Stefan Faderl, Guillermo Garcia-Manero, Jianquin Shan, Sherry Pierce, Jorge Cortes, Susan O'Brien

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18 Scopus citations

Abstract

The outcome of adults with acute lymphocytic leukemia (ALL) who achieve a complete response (CR) on salvage therapy is thought to be poor, but not previously analyzed. To define the course of adult ALL post CR on salvage therapy and the effects of pretreatment factors on prognosis. One hundred seventy-two adults with ALL who achieved a second or third CR on salvage therapy were reviewed. Prognostic factors affecting survival were analyzed by multivariate analysis. The median survival post achieving CR for the entire group was 10 months. The estimated 1-year survival rate was 42%. Forty-three patients underwent stem cell transplant in subsequent CR: their median survival was 12 months and the 3-year survival rate was 25%. Independent poor prognostic factors for survival were age > 55 years, duration of first CR< 12 months, and lactate dehydrogenase levels> 1000IU/L. This analysis defines the outcome of adult ALL in CR post salvage therapy and the prognostic factors influencing survival. These results could be used in assessing the efficacy of new treatments aimed at improving CR durations and survival post salvage therapy.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalLeukemia & lymphoma
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Kantarjian, H. M., Thomas, D., Ravandi, F., Faderl, S., Garcia-Manero, G., Shan, J., Pierce, S., Cortes, J., & O'Brien, S. (2010). Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. Leukemia & lymphoma, 51(3), 475-480. https://doi.org/10.3109/10428190903503412