Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission.

Hagop M. Kantarjian, Deborah Thomas, Farhad Ravandi, Stefan Faderl, Guillermo Garcia-Manero, Jianquin Shan, Sherry Pierce, Jorge Cortes, Susan O'Brien

Research output: Contribution to journalArticle

Abstract

The outcome of adults with acute lymphocytic leukemia (ALL) who achieve a complete response (CR) on salvage therapy is thought to be poor, but not previously analyzed. To define the course of adult ALL post CR on salvage therapy and the effects of pretreatment factors on prognosis. One hundred seventy-two adults with ALL who achieved a second or third CR on salvage therapy were reviewed. Prognostic factors affecting survival were analyzed by multivariate analysis. The median survival post achieving CR for the entire group was 10 months. The estimated 1-year survival rate was 42%. Forty-three patients underwent stem cell transplant in subsequent CR: their median survival was 12 months and the 3-year survival rate was 25%. Independent poor prognostic factors for survival were age > 55 years, duration of first CR< 12 months, and lactate dehydrogenase levels> 1000IU/L. This analysis defines the outcome of adult ALL in CR post salvage therapy and the prognostic factors influencing survival. These results could be used in assessing the efficacy of new treatments aimed at improving CR durations and survival post salvage therapy.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalLeukemia & lymphoma
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Salvage Therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival
Survival Rate
Stem Cells
Multivariate Analysis
Transplants

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Kantarjian, H. M., Thomas, D., Ravandi, F., Faderl, S., Garcia-Manero, G., Shan, J., ... O'Brien, S. (2010). Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. Leukemia & lymphoma, 51(3), 475-480. https://doi.org/10.3109/10428190903503412

Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. / Kantarjian, Hagop M.; Thomas, Deborah; Ravandi, Farhad; Faderl, Stefan; Garcia-Manero, Guillermo; Shan, Jianquin; Pierce, Sherry; Cortes, Jorge; O'Brien, Susan.

In: Leukemia & lymphoma, Vol. 51, No. 3, 01.03.2010, p. 475-480.

Research output: Contribution to journalArticle

Kantarjian, HM, Thomas, D, Ravandi, F, Faderl, S, Garcia-Manero, G, Shan, J, Pierce, S, Cortes, J & O'Brien, S 2010, 'Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission.', Leukemia & lymphoma, vol. 51, no. 3, pp. 475-480. https://doi.org/10.3109/10428190903503412
Kantarjian HM, Thomas D, Ravandi F, Faderl S, Garcia-Manero G, Shan J et al. Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. Leukemia & lymphoma. 2010 Mar 1;51(3):475-480. https://doi.org/10.3109/10428190903503412
Kantarjian, Hagop M. ; Thomas, Deborah ; Ravandi, Farhad ; Faderl, Stefan ; Garcia-Manero, Guillermo ; Shan, Jianquin ; Pierce, Sherry ; Cortes, Jorge ; O'Brien, Susan. / Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. In: Leukemia & lymphoma. 2010 ; Vol. 51, No. 3. pp. 475-480.
@article{52144a35f4c34f2faf980035e06d26eb,
title = "Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission.",
abstract = "The outcome of adults with acute lymphocytic leukemia (ALL) who achieve a complete response (CR) on salvage therapy is thought to be poor, but not previously analyzed. To define the course of adult ALL post CR on salvage therapy and the effects of pretreatment factors on prognosis. One hundred seventy-two adults with ALL who achieved a second or third CR on salvage therapy were reviewed. Prognostic factors affecting survival were analyzed by multivariate analysis. The median survival post achieving CR for the entire group was 10 months. The estimated 1-year survival rate was 42{\%}. Forty-three patients underwent stem cell transplant in subsequent CR: their median survival was 12 months and the 3-year survival rate was 25{\%}. Independent poor prognostic factors for survival were age > 55 years, duration of first CR< 12 months, and lactate dehydrogenase levels> 1000IU/L. This analysis defines the outcome of adult ALL in CR post salvage therapy and the prognostic factors influencing survival. These results could be used in assessing the efficacy of new treatments aimed at improving CR durations and survival post salvage therapy.",
author = "Kantarjian, {Hagop M.} and Deborah Thomas and Farhad Ravandi and Stefan Faderl and Guillermo Garcia-Manero and Jianquin Shan and Sherry Pierce and Jorge Cortes and Susan O'Brien",
year = "2010",
month = "3",
day = "1",
doi = "10.3109/10428190903503412",
language = "English (US)",
volume = "51",
pages = "475--480",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission.

AU - Kantarjian, Hagop M.

AU - Thomas, Deborah

AU - Ravandi, Farhad

AU - Faderl, Stefan

AU - Garcia-Manero, Guillermo

AU - Shan, Jianquin

AU - Pierce, Sherry

AU - Cortes, Jorge

AU - O'Brien, Susan

PY - 2010/3/1

Y1 - 2010/3/1

N2 - The outcome of adults with acute lymphocytic leukemia (ALL) who achieve a complete response (CR) on salvage therapy is thought to be poor, but not previously analyzed. To define the course of adult ALL post CR on salvage therapy and the effects of pretreatment factors on prognosis. One hundred seventy-two adults with ALL who achieved a second or third CR on salvage therapy were reviewed. Prognostic factors affecting survival were analyzed by multivariate analysis. The median survival post achieving CR for the entire group was 10 months. The estimated 1-year survival rate was 42%. Forty-three patients underwent stem cell transplant in subsequent CR: their median survival was 12 months and the 3-year survival rate was 25%. Independent poor prognostic factors for survival were age > 55 years, duration of first CR< 12 months, and lactate dehydrogenase levels> 1000IU/L. This analysis defines the outcome of adult ALL in CR post salvage therapy and the prognostic factors influencing survival. These results could be used in assessing the efficacy of new treatments aimed at improving CR durations and survival post salvage therapy.

AB - The outcome of adults with acute lymphocytic leukemia (ALL) who achieve a complete response (CR) on salvage therapy is thought to be poor, but not previously analyzed. To define the course of adult ALL post CR on salvage therapy and the effects of pretreatment factors on prognosis. One hundred seventy-two adults with ALL who achieved a second or third CR on salvage therapy were reviewed. Prognostic factors affecting survival were analyzed by multivariate analysis. The median survival post achieving CR for the entire group was 10 months. The estimated 1-year survival rate was 42%. Forty-three patients underwent stem cell transplant in subsequent CR: their median survival was 12 months and the 3-year survival rate was 25%. Independent poor prognostic factors for survival were age > 55 years, duration of first CR< 12 months, and lactate dehydrogenase levels> 1000IU/L. This analysis defines the outcome of adult ALL in CR post salvage therapy and the prognostic factors influencing survival. These results could be used in assessing the efficacy of new treatments aimed at improving CR durations and survival post salvage therapy.

UR - http://www.scopus.com/inward/record.url?scp=79955694768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955694768&partnerID=8YFLogxK

U2 - 10.3109/10428190903503412

DO - 10.3109/10428190903503412

M3 - Article

C2 - 20078325

AN - SCOPUS:79955694768

VL - 51

SP - 475

EP - 480

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 3

ER -