Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer

Xiaolong Yang, Yawei Hao, Alex Ferenczy, Shou-Ching Tang, Alan Pater

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Apoptosis is a programmed cell death process in which cells commit suicide under certain environmental conditions. Recent studies suggest that apoptosis is controlled by a variety of cellular genes, and dysregulation of these genes plays an important role in the pathogenesis of human diseases, including cancer. BAG-1 is a novel anti-apoptotic protein isolated by its interaction with another anti-apoptotic protein, Bcl-2. It binds to several hormone receptors and growth factor receptors and modulates their function in apoptosis. However, the role of BAG-1 in the oncogenesis of human cervical cancer has yet to be illustrated. In this study, we examined the expression of BAG-1 in cervical normal and carcinoma cultured cells and tissues. BAG-1 was overexpressed in human cervical carcinoma cell lines and tissues. Overexpression was regulated at the transcriptional level. The increased expression of BAG-1 was correlated with enhanced resistance of cervical carcinoma cells to apoptosis induced by a DNA-damaging reagent. In addition, overexpression of BAG-1 enhanced the resistance of cervical cells to apoptosis. This study provided the first evidence that BAG-1 is upregulated in human cervical cancer and may play an important role in apoptosis and human cervical carcinogenesis.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalExperimental Cell Research
Volume247
Issue number1
DOIs
StatePublished - Feb 25 1999

ASJC Scopus subject areas

  • Cell Biology

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