Palladium-catalyzed N-arylation of O-methylamidoximes

Mariappan Anbazhagan, Chad E. Stephens, David W. Boykin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Pd-catalyzed coupling of O-methylbenzamidoximes gave N-aryl O-methylbenzamidoximes using aryl halides with electron attracting or moderate electron donating groups. Under the same conditions, benzamidoxime failed to undergo coupling and O-acetylbenzamidoxime underwent cyclization to form the corresponding [1,2,4]oxadiazole.

Original languageEnglish (US)
Pages (from-to)4221-4224
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number23
DOIs
StatePublished - Jun 3 2002

Fingerprint

Palladium
Electrons
Oxadiazoles
Cyclization
benzamidoxime

Keywords

  • Aryl halides
  • Coupling reactions
  • N-aryl O-methylbenzamidoximes
  • Pd-catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Palladium-catalyzed N-arylation of O-methylamidoximes. / Anbazhagan, Mariappan; Stephens, Chad E.; Boykin, David W.

In: Tetrahedron Letters, Vol. 43, No. 23, 03.06.2002, p. 4221-4224.

Research output: Contribution to journalArticle

Anbazhagan, Mariappan ; Stephens, Chad E. ; Boykin, David W. / Palladium-catalyzed N-arylation of O-methylamidoximes. In: Tetrahedron Letters. 2002 ; Vol. 43, No. 23. pp. 4221-4224.
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