Palladium-catalyzed N-arylation of O-methylamidoximes

Mariappan Anbazhagan, Chad E. Stephens, David W. Boykin

Research output: Contribution to journalArticle

27 Scopus citations


Pd-catalyzed coupling of O-methylbenzamidoximes gave N-aryl O-methylbenzamidoximes using aryl halides with electron attracting or moderate electron donating groups. Under the same conditions, benzamidoxime failed to undergo coupling and O-acetylbenzamidoxime underwent cyclization to form the corresponding [1,2,4]oxadiazole.

Original languageEnglish (US)
Pages (from-to)4221-4224
Number of pages4
JournalTetrahedron Letters
Issue number23
StatePublished - Jun 3 2002
Externally publishedYes


  • Aryl halides
  • Coupling reactions
  • N-aryl O-methylbenzamidoximes
  • Pd-catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Anbazhagan, M., Stephens, C. E., & Boykin, D. W. (2002). Palladium-catalyzed N-arylation of O-methylamidoximes. Tetrahedron Letters, 43(23), 4221-4224.