Palmitate oxidation in human muscle: Comparison to CPT and carnitine

Jack B. Shumate, James E. Carroll, Michael H. Brooke, Rati M. Choksi

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The evaluation of palmitate oxidation in muscle tissue may be a useful screening test for detecting defects in fatty acid metabolism in human neuromuscular disease. If the test is to be useful, it is necessary to obtain data on a wide variety of muscle illnesses for comparative purposes. We report our experience with palmitate oxidation, muscle carnitine, and carnitine palmityl transferase (CPT) activity in 148 muscle biopsies from a variety of illnesses. The efficacy of using total protein, citrate synthase, and (1‐14C) pyruvate oxidation as internal references was investigated. Palmitate oxidation was significantly less than normal (P ≤ 0.01) in Duchenne muscular dystrophy, congenital nonprogressive myopathy, congenital muscular dystrophy, malignant hyperpyrexia, and denervation, depending on the internal reference used. Muscle carnitine levels followed a similar pattern, however, CPT activity did not. The possibility of these findings being secondary to inactivity is discussed.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalMuscle & Nerve
Volume5
Issue number3
DOIs
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Shumate, J. B., Carroll, J. E., Brooke, M. H., & Choksi, R. M. (1982). Palmitate oxidation in human muscle: Comparison to CPT and carnitine. Muscle & Nerve, 5(3), 226-231. https://doi.org/10.1002/mus.880050309