Papillary adenoma of the lung

C. A. Hegg, A. Flint, Gurmukh Singh

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Three cases of an unusual neoplasm of the lung appeared as solitary, peripheral pulmonary nodules in asymptomatic patients. These well- circumscribed neoplasms were composed of distinctive papillae covered by uniform cuboidal to columnar cells; more solid areas often were present. Ciliated cells, epithelial mucin, and necrosis were not observed, and mitotic activity was absent. Terminal tight junctions and microvilli were present in the two cases studied ultrastructurally. One specimen contained lamellar bodies and apical cytoplasmic dense bodies. Another case stained positively for a Clara cell-specific antigen, although surfactant apoprotein was not detected by immunostaining in the three cases. All patients have been free of disease (at 11 to 108 months). Papillary adenoma is an uncommon, apparently benign, and morphologically distinctive neoplasm. The immunohistochemical and ultrastructural findings hint at an origin from type II pneumocytes or Clara cells.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number3
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Adenoma
Solitary Pulmonary Nodule
Alveolar Epithelial Cells
Lung
Apoproteins
Tight Junctions
Mucins
Microvilli
Surface-Active Agents
Lung Neoplasms
Neoplasms
Necrosis
Epithelial Cells
Clara cell antigen

Keywords

  • Clara cells
  • Lung
  • Papillary adenoma
  • Type II pneumocytes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Papillary adenoma of the lung. / Hegg, C. A.; Flint, A.; Singh, Gurmukh.

In: American Journal of Clinical Pathology, Vol. 97, No. 3, 01.01.1992, p. 393-397.

Research output: Contribution to journalArticle

Hegg, C. A. ; Flint, A. ; Singh, Gurmukh. / Papillary adenoma of the lung. In: American Journal of Clinical Pathology. 1992 ; Vol. 97, No. 3. pp. 393-397.
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