Parental history of Type 2 diabetes in patients with nonaffective psychosis

Emilio Fernandez-Egea; Brian J Miller; Miguel Bernardo; Thomas Donner; Brian Kirkpatrick

doi:10.1016/j.schres.2007.10.002

Parental history of Type 2 diabetes in patients with nonaffective psychosis

Emilio Fernandez-Egea, Brian J Miller, Miguel Bernardo, Thomas Donner, Brian Kirkpatrick

Psychiatry and Health Behavior

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Introduction: We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands. Methods: N = 34 patients with newly-diagnosed nonaffective psychosis and N = 52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes. Results: In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p < 0.04). Discussion: We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.

Original language	English (US)
Pages (from-to)	302-306
Number of pages	5
Journal	Schizophrenia Research
Volume	98
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2007.10.002
State	Published - Jan 2008

Keywords

Epidemiology
Family history
Nonaffective psychosis
Schizophrenia
Type 2 diabetes

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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title = "Parental history of Type 2 diabetes in patients with nonaffective psychosis",

abstract = "Introduction: We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands. Methods: N = 34 patients with newly-diagnosed nonaffective psychosis and N = 52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes. Results: In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p < 0.04). Discussion: We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.",

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AU - Fernandez-Egea, Emilio

AU - Miller, Brian J

AU - Bernardo, Miguel

AU - Donner, Thomas

AU - Kirkpatrick, Brian

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AB - Introduction: We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands. Methods: N = 34 patients with newly-diagnosed nonaffective psychosis and N = 52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes. Results: In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p < 0.04). Discussion: We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.

KW - Epidemiology

KW - Family history

KW - Nonaffective psychosis

KW - Schizophrenia

KW - Type 2 diabetes

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Parental history of Type 2 diabetes in patients with nonaffective psychosis

Abstract

Keywords

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