Pathogenesis of intra-abdominal and pelvic adhesion development

Anthony N. Imudia, Sanjeev Kumar, Ghassan M. Saed, Michael Peter Diamond

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Abdominal and pelvic adhesions are a frequent occurrence and are responsible for significant morbidity resulting in abdominal and pelvic pain, infertility, and small bowel obstruction. The process of adhesion development begins when damage to peritoneal surfaces from any source (operative trauma, infection, foreign bodies, desiccation, irradiation, allergic reaction, or chemical injury) induces a series of biochemical/molecular biologic cascades involving different elements. These elements include peritoneal fluid, neutrophils, leukocytes, macrophages, cytokines, mesothelial cells, and tissue and coagulation factors, which ideologically have the intention of peritoneal repair; however, these processes also result in adhesion development. Major pathways that play significant roles in the healing process of peritoneal damage leading to adhesion development are the fibrinolytic system, extracellular matrix deposition, growth factor and cytokines, cell adhesion molecules, angiogenesis, apoptosis and proliferation, and remesothelialization. Greater understanding of the regulation and interaction of these processes provides the potential for reduction of postoperative adhesion development.

Original languageEnglish (US)
Pages (from-to)289-297
Number of pages9
JournalSeminars in Reproductive Medicine
Volume26
Issue number4
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

Fingerprint

Cytokines
Desiccation
Pelvic Pain
Blood Coagulation Factors
Ascitic Fluid
Wounds and Injuries
Cell Adhesion Molecules
Thromboplastin
Foreign Bodies
Infertility
Abdominal Pain
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Hypersensitivity
Neutrophils
Leukocytes
Epithelium
Macrophages
Apoptosis
Morbidity

Keywords

  • Adhesion re-formation
  • De novo adhesion formation
  • Development
  • Intra-abdominal
  • Pathogenesis
  • Pelvic
  • Postoperative adhesions

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

Cite this

Pathogenesis of intra-abdominal and pelvic adhesion development. / Imudia, Anthony N.; Kumar, Sanjeev; Saed, Ghassan M.; Diamond, Michael Peter.

In: Seminars in Reproductive Medicine, Vol. 26, No. 4, 01.07.2008, p. 289-297.

Research output: Contribution to journalReview article

Imudia, Anthony N. ; Kumar, Sanjeev ; Saed, Ghassan M. ; Diamond, Michael Peter. / Pathogenesis of intra-abdominal and pelvic adhesion development. In: Seminars in Reproductive Medicine. 2008 ; Vol. 26, No. 4. pp. 289-297.
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