Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens

Lyric C. Bartholomay, Robert M. Waterhouse, George F. Mayhew, Corey L. Campbell, Kristin Michel, Zhen Zou, Jose L. Ramirez, Suchismita Das, Kanwal Alvarez, Peter Arensburger, Bart Bryant, Sinead B. Chapman, Yuemei Dong, Sara M. Erickson, S. H.P. Parakrama Karunaratne, Vladimir Kokoza, Chinnappa D. Kodira, Patricia Pignatelli, Sang Woon Shin, Dana L. VanlandinghamPeter W. Atkinson, Bruce Birren, George K. Christophides, Rollie J. Clem, Janet Hemingway, Stephen Higgs, Karine Megy, Hilary Ranson, Evgeny M. Zdobnov, Alexander S. Raikhel, Bruce M. Christensen, George Dimopoulos, Marc A.T. Muskavitch

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalScience
Volume330
Issue number6000
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • General

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