Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies

Robert K. Yu, Toshio Ariga, Seigo Usuki, Ken Ichi Kaida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

Gangliosides, sialic acid-containing glycosphingolipids (GSLs), are a family of diverse, highly complex molecules localized primarily on the plasma membrane and particularly abundant in the nervous tissues of vertebrates. Research interest in gangliosides is not limited to their normal biological functions, such as neurotrophicity, cell-cell recognition and adhesion, cellular differentiation and growth, intercellular signaling, and trafficking and/or sorting [17, 19, 61, 62], or on the important constituents of cell surface microdomains or lipid rafts [18, 25, 44]. Research is also focused on the role of gangliosides in the pathogenic mechanisms of many immune-mediated neurological disorders, such as Guillain-Barré syndrome (GBS) [5, 57, 63]. For the putative pathogenic roles of gangliosides, accumulating evidence indicates that (a) gangliosides are localized in peripheral nerve system (PNS) myelin and axolemma, and degeneration of myelin and axons accounts for the loss of sensory and motor functions; (b) animal models of peripheral neuropathies can be established using certain pure gangliosides as the immunogens; and (c) the pathophysiological effects of the antibodies could be due to one or more of the following mechanisms: an antibody-mediated, complement-dependent process; a cell-mediated degenerating process; and a conduction block at the node of Ranvier.

Original languageEnglish (US)
Title of host publicationThe Molecular Immunology of Complex Carbohydrates-3
EditorsAlbert Wu
Pages349-365
Number of pages17
DOIs
StatePublished - Dec 19 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume705
ISSN (Print)0065-2598

Fingerprint

Gangliosides
Myelin Sheath
Ranvier's Nodes
Nerve Tissue
Glycosphingolipids
Antibodies
N-Acetylneuraminic Acid
Peripheral Nervous System Diseases
Cell membranes
Nervous System Diseases
Peripheral Nerves
Sorting
Research
Cell Adhesion
Axons
Vertebrates
Animals
Adhesion
Animal Models
Cell Membrane

Keywords

  • Antiganglioside antibodies
  • Autoantibodies against ganglioside -complex
  • Campylobacter jejuni
  • Guillain-Barré syndrome
  • Lipopolysaccharides
  • Molecular mimicry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yu, R. K., Ariga, T., Usuki, S., & Kaida, K. I. (2011). Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. In A. Wu (Ed.), The Molecular Immunology of Complex Carbohydrates-3 (pp. 349-365). (Advances in Experimental Medicine and Biology; Vol. 705). https://doi.org/10.1007/978-1-4419-7877-6_17

Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. / Yu, Robert K.; Ariga, Toshio; Usuki, Seigo; Kaida, Ken Ichi.

The Molecular Immunology of Complex Carbohydrates-3. ed. / Albert Wu. 2011. p. 349-365 (Advances in Experimental Medicine and Biology; Vol. 705).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yu, RK, Ariga, T, Usuki, S & Kaida, KI 2011, Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. in A Wu (ed.), The Molecular Immunology of Complex Carbohydrates-3. Advances in Experimental Medicine and Biology, vol. 705, pp. 349-365. https://doi.org/10.1007/978-1-4419-7877-6_17
Yu RK, Ariga T, Usuki S, Kaida KI. Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. In Wu A, editor, The Molecular Immunology of Complex Carbohydrates-3. 2011. p. 349-365. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-7877-6_17
Yu, Robert K. ; Ariga, Toshio ; Usuki, Seigo ; Kaida, Ken Ichi. / Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. The Molecular Immunology of Complex Carbohydrates-3. editor / Albert Wu. 2011. pp. 349-365 (Advances in Experimental Medicine and Biology).
@inproceedings{0b45519ab89e415b980d87c93e0ff80f,
title = "Pathological roles of ganglioside mimicry in guillain-barr{\'e} syndrome and related neuropathies",
abstract = "Gangliosides, sialic acid-containing glycosphingolipids (GSLs), are a family of diverse, highly complex molecules localized primarily on the plasma membrane and particularly abundant in the nervous tissues of vertebrates. Research interest in gangliosides is not limited to their normal biological functions, such as neurotrophicity, cell-cell recognition and adhesion, cellular differentiation and growth, intercellular signaling, and trafficking and/or sorting [17, 19, 61, 62], or on the important constituents of cell surface microdomains or lipid rafts [18, 25, 44]. Research is also focused on the role of gangliosides in the pathogenic mechanisms of many immune-mediated neurological disorders, such as Guillain-Barr{\'e} syndrome (GBS) [5, 57, 63]. For the putative pathogenic roles of gangliosides, accumulating evidence indicates that (a) gangliosides are localized in peripheral nerve system (PNS) myelin and axolemma, and degeneration of myelin and axons accounts for the loss of sensory and motor functions; (b) animal models of peripheral neuropathies can be established using certain pure gangliosides as the immunogens; and (c) the pathophysiological effects of the antibodies could be due to one or more of the following mechanisms: an antibody-mediated, complement-dependent process; a cell-mediated degenerating process; and a conduction block at the node of Ranvier.",
keywords = "Antiganglioside antibodies, Autoantibodies against ganglioside -complex, Campylobacter jejuni, Guillain-Barr{\'e} syndrome, Lipopolysaccharides, Molecular mimicry",
author = "Yu, {Robert K.} and Toshio Ariga and Seigo Usuki and Kaida, {Ken Ichi}",
year = "2011",
month = "12",
day = "19",
doi = "10.1007/978-1-4419-7877-6_17",
language = "English (US)",
isbn = "9781441978769",
series = "Advances in Experimental Medicine and Biology",
pages = "349--365",
editor = "Albert Wu",
booktitle = "The Molecular Immunology of Complex Carbohydrates-3",

}

TY - GEN

T1 - Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies

AU - Yu, Robert K.

AU - Ariga, Toshio

AU - Usuki, Seigo

AU - Kaida, Ken Ichi

PY - 2011/12/19

Y1 - 2011/12/19

N2 - Gangliosides, sialic acid-containing glycosphingolipids (GSLs), are a family of diverse, highly complex molecules localized primarily on the plasma membrane and particularly abundant in the nervous tissues of vertebrates. Research interest in gangliosides is not limited to their normal biological functions, such as neurotrophicity, cell-cell recognition and adhesion, cellular differentiation and growth, intercellular signaling, and trafficking and/or sorting [17, 19, 61, 62], or on the important constituents of cell surface microdomains or lipid rafts [18, 25, 44]. Research is also focused on the role of gangliosides in the pathogenic mechanisms of many immune-mediated neurological disorders, such as Guillain-Barré syndrome (GBS) [5, 57, 63]. For the putative pathogenic roles of gangliosides, accumulating evidence indicates that (a) gangliosides are localized in peripheral nerve system (PNS) myelin and axolemma, and degeneration of myelin and axons accounts for the loss of sensory and motor functions; (b) animal models of peripheral neuropathies can be established using certain pure gangliosides as the immunogens; and (c) the pathophysiological effects of the antibodies could be due to one or more of the following mechanisms: an antibody-mediated, complement-dependent process; a cell-mediated degenerating process; and a conduction block at the node of Ranvier.

AB - Gangliosides, sialic acid-containing glycosphingolipids (GSLs), are a family of diverse, highly complex molecules localized primarily on the plasma membrane and particularly abundant in the nervous tissues of vertebrates. Research interest in gangliosides is not limited to their normal biological functions, such as neurotrophicity, cell-cell recognition and adhesion, cellular differentiation and growth, intercellular signaling, and trafficking and/or sorting [17, 19, 61, 62], or on the important constituents of cell surface microdomains or lipid rafts [18, 25, 44]. Research is also focused on the role of gangliosides in the pathogenic mechanisms of many immune-mediated neurological disorders, such as Guillain-Barré syndrome (GBS) [5, 57, 63]. For the putative pathogenic roles of gangliosides, accumulating evidence indicates that (a) gangliosides are localized in peripheral nerve system (PNS) myelin and axolemma, and degeneration of myelin and axons accounts for the loss of sensory and motor functions; (b) animal models of peripheral neuropathies can be established using certain pure gangliosides as the immunogens; and (c) the pathophysiological effects of the antibodies could be due to one or more of the following mechanisms: an antibody-mediated, complement-dependent process; a cell-mediated degenerating process; and a conduction block at the node of Ranvier.

KW - Antiganglioside antibodies

KW - Autoantibodies against ganglioside -complex

KW - Campylobacter jejuni

KW - Guillain-Barré syndrome

KW - Lipopolysaccharides

KW - Molecular mimicry

UR - http://www.scopus.com/inward/record.url?scp=80054021668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054021668&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-7877-6_17

DO - 10.1007/978-1-4419-7877-6_17

M3 - Conference contribution

C2 - 21618117

AN - SCOPUS:80054021668

SN - 9781441978769

T3 - Advances in Experimental Medicine and Biology

SP - 349

EP - 365

BT - The Molecular Immunology of Complex Carbohydrates-3

A2 - Wu, Albert

ER -