Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies

Robert K. Yu, Toshio Ariga, Seigo Usuki, Ken Ichi Kaida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations

Abstract

Gangliosides, sialic acid-containing glycosphingolipids (GSLs), are a family of diverse, highly complex molecules localized primarily on the plasma membrane and particularly abundant in the nervous tissues of vertebrates. Research interest in gangliosides is not limited to their normal biological functions, such as neurotrophicity, cell-cell recognition and adhesion, cellular differentiation and growth, intercellular signaling, and trafficking and/or sorting [17, 19, 61, 62], or on the important constituents of cell surface microdomains or lipid rafts [18, 25, 44]. Research is also focused on the role of gangliosides in the pathogenic mechanisms of many immune-mediated neurological disorders, such as Guillain-Barré syndrome (GBS) [5, 57, 63]. For the putative pathogenic roles of gangliosides, accumulating evidence indicates that (a) gangliosides are localized in peripheral nerve system (PNS) myelin and axolemma, and degeneration of myelin and axons accounts for the loss of sensory and motor functions; (b) animal models of peripheral neuropathies can be established using certain pure gangliosides as the immunogens; and (c) the pathophysiological effects of the antibodies could be due to one or more of the following mechanisms: an antibody-mediated, complement-dependent process; a cell-mediated degenerating process; and a conduction block at the node of Ranvier.

Original languageEnglish (US)
Title of host publicationThe Molecular Immunology of Complex Carbohydrates-3
EditorsAlbert Wu
Pages349-365
Number of pages17
DOIs
Publication statusPublished - Dec 19 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume705
ISSN (Print)0065-2598

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Keywords

  • Antiganglioside antibodies
  • Autoantibodies against ganglioside -complex
  • Campylobacter jejuni
  • Guillain-Barré syndrome
  • Lipopolysaccharides
  • Molecular mimicry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yu, R. K., Ariga, T., Usuki, S., & Kaida, K. I. (2011). Pathological roles of ganglioside mimicry in guillain-barré syndrome and related neuropathies. In A. Wu (Ed.), The Molecular Immunology of Complex Carbohydrates-3 (pp. 349-365). (Advances in Experimental Medicine and Biology; Vol. 705). https://doi.org/10.1007/978-1-4419-7877-6_17