Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users: A latent transition analysis of the CIDUS 3/DUIT study

Mary E. MacKesy-Amiti, Lorna Finnegan, Lawrence J. Ouellet, Elizabeth T. Golub, Holly Hagan, Sharon M. Hudson, Mary H. Latka, Richard S. Garfein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.

Original languageEnglish (US)
Pages (from-to)2075-2083
Number of pages9
JournalAIDS and Behavior
Volume17
Issue number6
DOIs
StatePublished - Jul 1 2013

Fingerprint

Risk-Taking
Drug Users
Education
Injections
Needle Sharing
HIV
Control Groups
Equipment and Supplies

Keywords

  • HCV
  • HIV
  • Injection drug use
  • Intervention
  • Latent class analysis

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users : A latent transition analysis of the CIDUS 3/DUIT study. / MacKesy-Amiti, Mary E.; Finnegan, Lorna; Ouellet, Lawrence J.; Golub, Elizabeth T.; Hagan, Holly; Hudson, Sharon M.; Latka, Mary H.; Garfein, Richard S.

In: AIDS and Behavior, Vol. 17, No. 6, 01.07.2013, p. 2075-2083.

Research output: Contribution to journalArticle

MacKesy-Amiti, Mary E. ; Finnegan, Lorna ; Ouellet, Lawrence J. ; Golub, Elizabeth T. ; Hagan, Holly ; Hudson, Sharon M. ; Latka, Mary H. ; Garfein, Richard S. / Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users : A latent transition analysis of the CIDUS 3/DUIT study. In: AIDS and Behavior. 2013 ; Vol. 17, No. 6. pp. 2075-2083.
@article{f8c06abe33334c6db97e2e30413ede65,
title = "Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users: A latent transition analysis of the CIDUS 3/DUIT study",
abstract = "We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 {\%} more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.",
keywords = "HCV, HIV, Injection drug use, Intervention, Latent class analysis",
author = "MacKesy-Amiti, {Mary E.} and Lorna Finnegan and Ouellet, {Lawrence J.} and Golub, {Elizabeth T.} and Holly Hagan and Hudson, {Sharon M.} and Latka, {Mary H.} and Garfein, {Richard S.}",
year = "2013",
month = "7",
day = "1",
doi = "10.1007/s10461-012-0373-0",
language = "English (US)",
volume = "17",
pages = "2075--2083",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users

T2 - A latent transition analysis of the CIDUS 3/DUIT study

AU - MacKesy-Amiti, Mary E.

AU - Finnegan, Lorna

AU - Ouellet, Lawrence J.

AU - Golub, Elizabeth T.

AU - Hagan, Holly

AU - Hudson, Sharon M.

AU - Latka, Mary H.

AU - Garfein, Richard S.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.

AB - We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.

KW - HCV

KW - HIV

KW - Injection drug use

KW - Intervention

KW - Latent class analysis

UR - http://www.scopus.com/inward/record.url?scp=84879007128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879007128&partnerID=8YFLogxK

U2 - 10.1007/s10461-012-0373-0

DO - 10.1007/s10461-012-0373-0

M3 - Article

C2 - 23142857

AN - SCOPUS:84879007128

VL - 17

SP - 2075

EP - 2083

JO - AIDS and Behavior

JF - AIDS and Behavior

SN - 1090-7165

IS - 6

ER -