Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users: A latent transition analysis of the CIDUS 3/DUIT study

Mary E. MacKesy-Amiti, Lorna Finnegan, Lawrence J. Ouellet, Elizabeth T. Golub, Holly Hagan, Sharon M. Hudson, Mary H. Latka, Richard S. Garfein

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.

Original languageEnglish (US)
Pages (from-to)2075-2083
Number of pages9
JournalAIDS and Behavior
Volume17
Issue number6
DOIs
StatePublished - Jul 2013

Keywords

  • HCV
  • HIV
  • Injection drug use
  • Intervention
  • Latent class analysis

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    MacKesy-Amiti, M. E., Finnegan, L., Ouellet, L. J., Golub, E. T., Hagan, H., Hudson, S. M., Latka, M. H., & Garfein, R. S. (2013). Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users: A latent transition analysis of the CIDUS 3/DUIT study. AIDS and Behavior, 17(6), 2075-2083. https://doi.org/10.1007/s10461-012-0373-0