Abstract
We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2075-2083 |
| Number of pages | 9 |
| Journal | AIDS and Behavior |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jul 1 2013 |
Fingerprint
Keywords
- HCV
- HIV
- Injection drug use
- Intervention
- Latent class analysis
ASJC Scopus subject areas
- Social Psychology
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users : A latent transition analysis of the CIDUS 3/DUIT study. / MacKesy-Amiti, Mary E.; Finnegan, Lorna; Ouellet, Lawrence J.; Golub, Elizabeth T.; Hagan, Holly; Hudson, Sharon M.; Latka, Mary H.; Garfein, Richard S.
In: AIDS and Behavior, Vol. 17, No. 6, 01.07.2013, p. 2075-2083.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peer-education intervention to reduce injection risk behaviors benefits high-risk young injection drug users
T2 - A latent transition analysis of the CIDUS 3/DUIT study
AU - MacKesy-Amiti, Mary E.
AU - Finnegan, Lorna
AU - Ouellet, Lawrence J.
AU - Golub, Elizabeth T.
AU - Hagan, Holly
AU - Hudson, Sharon M.
AU - Latka, Mary H.
AU - Garfein, Richard S.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.
AB - We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.
KW - HCV
KW - HIV
KW - Injection drug use
KW - Intervention
KW - Latent class analysis
UR - http://www.scopus.com/inward/record.url?scp=84879007128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879007128&partnerID=8YFLogxK
U2 - 10.1007/s10461-012-0373-0
DO - 10.1007/s10461-012-0373-0
M3 - Article
C2 - 23142857
AN - SCOPUS:84879007128
VL - 17
SP - 2075
EP - 2083
JO - AIDS and Behavior
JF - AIDS and Behavior
SN - 1090-7165
IS - 6
ER -