Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sandhyamayee Sahu, Iryna O. Lebedyeva, Siva S. Panda, Alan R. Katritzky

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.

Original languageEnglish (US)
Article numberSS-2012-M0978-OP
Pages (from-to)1256-1260
Number of pages5
JournalSynthesis (Germany)
Volume45
Issue number9
DOIs
StatePublished - Apr 11 2013
Externally publishedYes

Keywords

  • acylations
  • cyclizations
  • drugs
  • heterocycles
  • nitriles
  • peptides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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