Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups

Sandhyamayee Sahu, Iryna Oleksandrivna Lebedyeva, Siva Shankar Panda, Alan R. Katritzky

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Peptidoyl benzotriazoles permit the acylation of active methylene groups of nitriles to provide CH-acylated nitrile enols from α-amino acids or from di- or tripeptides with no loss of chirality.

Original languageEnglish (US)
Article numberSS-2012-M0978-OP
Pages (from-to)1256-1260
Number of pages5
JournalSynthesis (Germany)
Volume45
Issue number9
DOIs
StatePublished - Apr 11 2013

Fingerprint

Acylation
Nitriles
Chirality
Amino acids
Dipeptides
Amino Acids
benzotriazole

Keywords

  • acylations
  • cyclizations
  • drugs
  • heterocycles
  • nitriles
  • peptides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

Peptidoyl benzotriazolide-mediated acylation of nitrile-activated methylene groups. / Sahu, Sandhyamayee; Lebedyeva, Iryna Oleksandrivna; Panda, Siva Shankar; Katritzky, Alan R.

In: Synthesis (Germany), Vol. 45, No. 9, SS-2012-M0978-OP, 11.04.2013, p. 1256-1260.

Research output: Contribution to journalArticle

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