Periodontal disease: links with serum lipid/ triglyceride levels? Review and new data.

Christopher W Cutler, Anthony M. Iacopino

Research output: Contribution to journalReview article

32 Scopus citations


Evidence now supports an intriguing role for serum lipids/triglycerides in modulation of the host immune response to infection. This paper will review the studies that have been conducted in humans and various animal models of the association between elevated serum lipids/triglycerides (i.e. hyperlipidaemia) and periodontitis (PD). We will also present new data in rats that suggests a bi-directional relationship between hyperlipidaemia and PD, i.e. that PD itself may be able to modulate serum lipid levels. This review will introduce evidence from other studies that the type of dietary lipids is important in the modulation of the immune/inflammatory response. Overall, the studies presented herein suggest that further investigation using epidemiological and experimental approaches is warranted.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalJournal of the International Academy of Periodontology
Issue number2
Publication statusPublished - Jan 1 2003
Externally publishedYes


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